IL-34 蛋白
This Recombinant IL-34 protein is expressed in CHO Cells.
产品编号 ABIN2666711
发货至:
中国
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Quick Overview for IL-34 蛋白 (ABIN2666711)
抗原
See all IL-34 (IL34) 蛋白
IL-34 (IL34)
(Interleukin 34 (IL34))
蛋白类型
Recombinant
宿主
人
资源
CHO Cells
应用范围
Flow Cytometry (FACS)
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过滤
- 0.22 μm filtered
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Interleukin 34 (IL34) (AA 21-242) protein (His tag)
IL34 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 85 % SDS
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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溶解方式
- For maximum results, quick spin vial prior to opening. The protein can be aliquoted and stored from -20 °C to -70 °C. Stock solutions can also be prepared at 50-100 μg/mL in sterile buffer (PBS, HPBS, DPBS, or EBSS) containing carrier protein such as 0.2-1 % BSA or HSA and stored in working aliquots at -20 °C to -70 °C.
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缓冲液
- 0.22 μm filtered protein solution is in 10 mM NaH2PO4, 0.5 M NaCl, pH 7.4.
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注意事项
- Avoid repeated freeze/thaw cycles.
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储存条件
- -20 °C
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储存方法
- Unopened vial can be stored between 2°C and 8°C for one month, at -20°C for six months, or at -70°C for one year.
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- IL-34 (IL34) (Interleukin 34 (IL34))
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别名
- IL-34
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背景
- Human IL-34 shares a sequence identity of 99.6 % , 72 % and 71 % with chimpanzee, rat, and mouse IL-34, respectively, on the amino acid level. The IL-34 gene is syntenic in the human, chimpanzee, rat, and mouse genomes. IL-34 has no apparent consensus structural domain or motif, and does not share sequence homology with M-CSF, nevertheless, it binds to the CSFR. These two cytokines are not identical in biological activity and signal activation. IL-34 and CSF show an equivalent ability to support cell growth or survival. However, these cytokines have differing ability to induce the production of chemokines (MCP-1 and eotaxin-2) in primary macrophages, the morphological change in TF-1-fms cells, and the migration of J774A.1 cells. The use of monoclonal antibodies against the CSFR suggests a differential domain binding in the receptor to IL-34 and CSF and, as a result, different bioactivities and signal activation kinetics/strength are produced for these cytokines.
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途径
- RTK signaling
抗原
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