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CXCL10 Protein (AA 22-98)

CXCL10 宿主: 小鼠 宿主: 大肠杆菌(E. Coli) Recombinant > 98 % , as determined by Coomassie stained SDS-PAGE. MA Active
产品编号 ABIN2666632
发货至: 中国
  • 抗原 See all CXCL10 蛋白
    CXCL10 (Chemokine (C-X-C Motif) Ligand 10 (CXCL10))
    蛋白类型
    Recombinant
    生物活性
    Active
    产品特性
    AA 22-98
    宿主
    • 15
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    小鼠
    资源
    • 23
    • 5
    • 3
    • 3
    • 1
    • 1
    • 1
    大肠杆菌(E. Coli)
    应用范围
    Multiplex Assay (MA)
    纯度
    > 98 % , as determined by Coomassie stained SDS-PAGE.
    过滤
    0.22 μm filtered
    内毒素水平

    Less than 0.01 ng per μg cytokine as determined by the LAL method.

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    Discover our top product CXCL10 蛋白
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    说明

    Biological activity: Bioactivity was measured by its property to chemoattract PHA, IL-2 activated T cells in a dose dependent manner.

    限制
    仅限研究用
  • 状态
    Liquid
    溶解方式
    For maximum results, quick spin vial prior to opening. The protein can be aliquoted and stored from -20 °C to -70 °C. Stock solutions can also be prepared at 50-100 μg/mL in sterile buffer (PBS, HPBS, DPBS, or EBSS) containing carrier protein such as 0.2-1 % BSA or HSA and stored in working aliquots at -20 °C to -70 °C.
    缓冲液
    0.22 μm filtered protein solution is in PBS.
    注意事项
    Avoid repeated freeze/thaw cycles.
    储存条件
    -20 °C
    储存方法
    Unopened vial can be stored between 2°C and 8°C for one month, at -20°C for six months, or at -70°C for one year.
  • 抗原
    CXCL10 (Chemokine (C-X-C Motif) Ligand 10 (CXCL10))
    别名
    CXCL10 (CXCL10 产品)
    别名
    CXCL10 Protein, C7 Protein, IFI10 Protein, INP10 Protein, IP-10 Protein, SCYB10 Protein, crg-2 Protein, gIP-10 Protein, mob-1 Protein, CRG-2 Protein, IP10 Protein, Ifi10 Protein, Scyb10 Protein, C-X-C motif chemokine ligand 10 Protein, C-X-C motif chemokine 10 Protein, chemokine (C-X-C motif) ligand 10 Protein, CXCL10 Protein, cxl10 Protein, Cxcl10 Protein
    背景
    CXCL10 is an ELR-negative chemokine structurally and functionally related to CXCL9 and CXCL11. CXCL10, CXCL9, and CXCL11 are produced and secreted by monocytes, macrophages, fibroblasts, and epithelial cells upon stimulation with proinflammatory cytokines, especially IFNγ. CXCL10 chemoattracts CD4, CD8, and NK and NKT cells through the binding to its receptor CXCR3, which is shared with CXCL9 and CXCL11. In addition, CXCL10 inhibits neovascularization in tumors and in wound healing in vivo. Also, CXCL10 has anti-proliferative effects on endothelial cells in vitro, and angiostatic and antitumor effects in vivo. It has been suggested that the anti-proliferative effect of CXCL10 in endothelial cells is CXCR3-independent and that it is mediated through GAG interaction. CXCL10 also possesses antimicrobial activity against E. coli and L. monocytogenes, and both the spore and bacillus forms of B. anthracis. CXCL10 expression is strongly upregulated in many inflammatory diseases, including arthritis, type I diabetes, experimental autoimmune encepahlomyelitis, atherosclerosis, allograft rejection, and others.
    分子量
    The 78 amino acid recombinant protein has a predicted molecular mass of approximately 8.8 kDa. The DTT-reduced and non-reduced protein migrate at approximately 10 kDa by SDS-PAGE. The N-terminal amino acid is Met.
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