我们推荐在您的浏览器上开启Javascript，以获得最佳效果。

Oncostatin M Protein (OSM) (AA 26-221)

Name: Oncostatin M Protein (OSM) (AA 26-221)
SKU: ABIN2666535
Availability: OutOfStock

This Recombinant Oncostatin M protein is expressed in 大肠杆菌（E. Coli）.

产品编号 ABIN2666535

发货至: 中国

Quick Overview for Oncostatin M Protein (OSM) (AA 26-221) (ABIN2666535)

抗原

See all Oncostatin M (OSM) 蛋白

Oncostatin M (OSM)

蛋白类型

Recombinant

生物活性

Active

宿主

人

资源

大肠杆菌（E. Coli）

应用范围

Flow Cytometry (FACS)

纯度

> 95 % , as determined by Coomassie stained SDS-PAGE.

Discover our top product OSM 蛋白

产品特性

AA 26-221

过滤

0.22 μm filtered

内毒素水平

Less than 0.01 ng per μg cytokine as determined by the LAL method.
想要此Protein的其他选项吗？

!

探索我们的预定义定制蛋白和定制蛋白服务！

您的项目需要进一步定制吗？联系我们，了解我们的定制蛋白解决方案

Oncostatin M (OSM) (AA 26-221) protein (His-Avi Tag)
OSM 宿主: 人宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Oncostatin M (OSM) (AA 25-206) protein (His tag)
OSM 宿主: 小鼠宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Oncostatin M (OSM) (AA 26-221) protein (His-Avi Tag,Biotin)
OSM 宿主: 人宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Oncostatin M (OSM) (AA 26-221) protein (His tag)
OSM 宿主: 人宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA

Oncostatin M (OSM) (AA 26-239) protein (His tag)
OSM 宿主: 大鼠宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA

Oncostatin M (OSM) (AA 1-252) protein (GST tag)
OSM 宿主: 人宿主: 小麦胚 Recombinant WB, ELISA, AP, AA

Oncostatin M (OSM) (AA 26-234) protein (His tag)
OSM 宿主: 人宿主: 大肠杆菌（E. Coli） Recombinant > 95 % by SDS - PAGE SDS

Oncostatin M (OSM) protein (His tag)
OSM 宿主: 人宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by reducing SDS-PAGE.

Oncostatin M (OSM) (AA 26-252) protein
OSM 宿主: 人宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.

Oncostatin M (OSM) protein
OSM 宿主: 人 Recombinant BCA

应用备注

Optimal working dilution should be determined by the investigator.

说明

Biological activity: ED50 = 0.5 - 2.5 ng/ml, corresponding to a specific activity of 0.4 - 2.0 x 106

限制

仅限研究用
状态

Liquid

溶解方式

For maximum results, quick spin vial prior to opening. Stock solutions can also be prepared at 50 - 100 μg/mL in sterile buffer (PBS, HPBS, DPBS, or EBSS) containing carrier protein such as 0.2 - 1 % BSA or HSA and stored in working aliquots at -20 °C to -70 °C.

缓冲液

0.22 μm filtered protein solution is in <20 % ACN, 0.1 % TFA.

注意事项

Avoid repeated freeze/thaw cycles.

储存条件

-20 °C

储存方法

Unopened vial can be stored between 2°C and 8°C for one month, at -20°C for six months, or at -70°C for one year.
抗原

Oncostatin M (OSM)

别名

Oncostatin M

背景

Human oncostatin M (OSM) was initially isolated from supernatant of U937 cells treated with PMA. It was identified by its property to inhibit the proliferation of A375 melanoma cells and other human tumor cells. Bioinformatic homology analysis reveals that OSM has a similar composition and structure to LIF, G-CSF, and IL-6. OSM and LIF are located on human chromosome 22, and additional evidence suggests that these genes were derived by duplication of a common ancestral gene. In fact, many of its biological functions are shared with LIF. OSM binds two types of OSM receptor (OSMR) complexes. The type I receptor complex is composed of gp130 (IL-6 signal transducer) and LIF receptor β (LIFRβ) subunits. The type II receptor is constituted by the gp130 receptor and the OSMR β-chain. OSM also shares the OSMRβ-chain with the IL-31 receptor complex. The OSMRβ subunit is expressed by fibroblast, endothelial, hepatic, lung, and hematopoietic cells. The proinflammatory properties of OSM have been reported in skin, adipose tissue, lung, heart, and liver tissues. OSM triggers acute phase protein synthesis in hepatocytes. OSM is a potent inhibitor of keratinocyte proliferation and decreases the expression of both early and late keratinocyte differentiation markers. OSM transcripts are elevated in skin from psoriasis and atopic dermatitis patients, as compared with healthy skin. OSM and its receptor complexes play a key role in cutaneous inflammatory responses. In addition, OSM expression is increased in colonic biopsies of patients with active inflammatory bowel disease.

分子量

The 196 amino acid recombinant protein has a predicted molecular mass of approximately 22.1 kDa. The DTT-reduced and non-reduced protein migrate at approximately 20 kDa and 22 kDa, respectively, by SDS-PAGE. The predicted N-terminal amino acid is Ala.

途径

JAK/STAT Signaling, Negative Regulation of Hormone Secretion