BMP6 Protein (AA 344-460)
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- 抗原 See all BMP6 蛋白
- BMP6 (Bone Morphogenetic Protein 6 (BMP6))
- 蛋白类型
- Recombinant
- 生物活性
- Active
- 产品特性
- AA 344-460
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宿主
- 人
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资源
- HEK-293 Cells
- 应用范围
- Multiplex Assay (MA)
- 纯度
- > 95 % , as determined by Coomassie stained SDS-PAGE and HPLC analysis.
- 内毒素水平
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Less than 0.1 ng per μg of protein.
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Bone Morphogenetic Protein 6 (BMP6) (AA 382-471) protein (GST tag)
BMP6 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Bone Morphogenetic Protein 6 (BMP6) (AA 382-513), (partial) protein (His tag)BMP6 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % SDS
Bone Morphogenetic Protein 6 (BMP6) proteinBMP6 宿主: 大鼠 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % SDS, WB, ELISA, IP
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 说明
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Biological activity: BMP-6 induces alkaline phosphatase production on ATDC-5 cells. The ED50 = 0.03 - 0.06 μg/ml, corresponding to a specific activity of 1.6 - 3.3 x 104 unit/mg.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- For maximum results, quick spin vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. Do not vortex. It is recommended to further dilute in a buffer containing a carrier protein such as 0.1 % BSA and store working aliquots at -20 °C to -80 °C.
- 缓冲液
- Lyophilized
- 注意事项
- Avoid repeated freeze/thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- Unopened vial can be stored at -20°C or -70°C.
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- 抗原
- BMP6 (Bone Morphogenetic Protein 6 (BMP6))
- 别名
- BMP-6 (BMP6 产品)
- 别名
- BMP6 Protein, zgc:113595 Protein, vgr Protein, vgr-1 Protein, vgr1 Protein, VGR Protein, VGR1 Protein, D13Wsu115e Protein, Vgr1 Protein, bone morphogenetic protein 6 Protein, bone morphogenetic protein 6 S homeolog Protein, BMP6 Protein, bmp6 Protein, bmp6.S Protein, Bmp6 Protein
- 背景
- Bone morphogenetic proteins (BMPs) belong to the transforming growth factor beta (TGF-β) superfamily. BMPs play a key role in embryonic development, especially during heart, neural, and cartilage development. Around 20 BMP family members have been identified and characterized. BMPs signal through serine/threonine kinase receptors, composed of type I and II subtypes. Four type I receptors have been identified: type IA and IB BMP receptors, type IA activin receptor, and activin receptor-like kinase I (ALK-1). Three type II receptors have also been recognized: type II BMP receptor and type II and IIB activin receptors. Human recombinant BMP-6 can restore bone in animal models of osteoporosis. BMP-6 induces bone formation through IGF-I and EGF pathways in a murine model of osteopenia and in human osteoblasts. BMP-6 has been reported to have an antiproliferative effect on B, T cells, and macrophages. Also, BMP-6 induced expression of pro-inflammatory inducible nitric oxide synthase (iNOS), TNF-α and IL-1β in macrophages. In addition, BMP-6 is a key endogenous regulator of hepcidin expression and iron metabolism in vivo. In fact, BMP-6 null mice have a phenotype that resembles mouse models of juvenile hemochromatosis (an iron overload disorder caused by mutations in the genes encoding the major iron regulatory hormone hepcidin and hemojuvelin).
- 分子量
- The 117 amino acid recombinant protein has a predicted molecular mass of approximately 13 kDa. Recombinant human BMP-6 is a 26.2 kDa homodimeric glycoprotein. The predicted N-terminal amino acid is Val.
- 途径
- Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process
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