BMP5 Protein (AA 317-454)
Quick Overview for BMP5 Protein (AA 317-454) (ABIN2666463)
抗原
See all BMP5 蛋白蛋白类型
生物活性
宿主
资源
应用范围
纯度
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产品特性
- AA 317-454
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内毒素水平
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Less than 0.1 ng per μg of protein.
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Bone Morphogenetic Protein 5 (BMP5) (AA 317-454) protein
BMP5 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % by SDS - PAGE SDS
Bone Morphogenetic Protein 5 (BMP5) (AA 1-454) protein (GST tag)BMP5 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
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应用备注
- Optimal working dilution should be determined by the investigator.
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说明
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Biological activity: BMP-5 induces alkaline phosphatase production on ATDC-5 cells. The expected ED50 = 0.5 - 1.0 μg/ml, corresponding to a specific activity of 1.0 - 2.0 x 103 unit/mg.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- For maximum results, quick spin vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. Do not vortex. It is recommended to further dilute in a buffer containing a carrier protein such as 0.1 % BSA and store working aliquots at -20 °C to -80 °C.
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缓冲液
- Lyophilized
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注意事项
- Avoid repeated freeze/thaw cycles.
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储存条件
- -20 °C
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储存方法
- Unopened vial can be stored at -20°C or -70°C.
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- BMP5 (Bone Morphogenetic Protein 5 (BMP5))
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别名
- BMP-5
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背景
- Bone morphogenetic proteins (BMPs) are multi-functional growth factors that belong to the transforming growth factor beta (TGF-β) superfamily. BMPs play a key role in embryonic development, especially during heart, neural, and cartilage development. Around 20 BMP family members have been identified and characterized. BMPs signal through serine/threonine kinase receptors, composed of type I and II subtypes. Four type I receptors have been identified: type IA and IB BMP receptors, type IA activin receptor, and activin receptor-like kinase I. Three type II receptors have also been recognized: type II BMP receptor and type II and IIB activin receptors. Nervous system development involves several BMPs including BMP-2, 4, 5, and 7. BMP-5 is widely expressed in the nervous system throughout development and into adulthood, and BMP-5 induces multiple dendritic processes to sympathetic neurons in culture. BMP-5 plays an important role in fracture healing during the stage of cartilage formation and periosteal response. In addition, BMP-4 and BMP-5 are expressed in normal synovial tissue and have been found to be decreased in osteoarthritis and rheumatoid arthritis, therefore, it has been speculated that these BMPs are important in joint homeostasis.
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分子量
- The 138 amino acid recombinant protein has a predicted molecular mass of approximately 15.6 kDa. Recombinant human BMP-5 is a homodimeric disulfide-linked protein. The predicted N-terminal amino acid is Ala.
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途径
- Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process
抗原
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