DLL1 蛋白
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北京 101111
Quick Overview for DLL1 蛋白 (ABIN2469061)
抗原
See all DLL1 蛋白蛋白类型
生物活性
宿主
资源
纯度
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序列
- SGVFELKLQE FVNKKGLLGN RNCCRGGAGP PPCACRTFFR VCLKHYQASV SPEPPCTYGS AVTPVLGVDS FSLPDGGGAD SAFSNPIRFP FGFTWPGTFS LIIEALHTDS PDDLATENPE RLISRLATQR HLTVGEEWSQ DLHSSGRTDL KYSYRFVCDE HYYGEGCSVF CRPRDDAFGH FTCGERGEKV CNPGWKGPYC TEPICLPGCD EQHGFCDKPG ECKCRVGWQG RYCDECIRYP GCLHGTCQQP WQCNCQEGWG GLFCNQDLNY CTHHKPCKNG ATCTNTGQGS YTCSCRPGYT GATCELGIDE CDPSPCKNGG SCTDLENSYS CTCPPGFYGK ICELSAMTCA DGPCFNGGRC SDSPDGGYSC RCPVGYSGFN CEKKIDYCSS SPCSNGAKCV DLGDAYLCRC QAGFSGRHCD DNVDDCASSP CANGGTCRDG VNDFSCTCPP GYTGRNCSAP VSRCEHAPCH NGATCHERGH RYVCECARGY GGPNCQFLLP ELPPGPAVVD LTEKLEGQGG PF
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产品特性
- Biological activity was determined by the dose dependent growth suppression of the human acute monocytic leukemia cell line, THP - 1. sDLL - 1 inhibits the proliferation in THP - 1 cells using a concentration of 3.0 - 5.0 μg/mL.
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内毒素水平
- Endotoxin level is less than 0.1 ng per μg (1 EU/μg).
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delta-Like 1 (DLL1) protein (Fc Tag)
DLL1 宿主: 人 宿主: 人细胞 Recombinant >95 % as determined by reducing SDS-PAGE.
delta-Like 1 (DLL1) (Active) protein (His tag)DLL1 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE Active
delta-Like 1 (DLL1) (AA 18-545) (Active) protein (Fc Tag)DLL1 宿主: 人 宿主: CHO Cells Recombinant >90 % (SDS-PAGE) SDS Active
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限制
- 仅限研究用
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状态
- Lyophilized
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注意事项
- As with any protein, exposing sDLL-1 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
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储存条件
- -20 °C
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储存方法
- The recombinant protein is stable for at least 2 years from date of receipt at -20 °C. Reconstituted sDLL-1 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20 °C.
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有效期
- 24 months
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- DLL1 (delta-Like 1 (DLL1))
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别名
- sDLL-1
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背景
- Human sDLL-1 comprises the extracellular signaling domain of DLL1, a member of a structurally-related family of single-pass type I trans-membrane proteins that serve as ligands for Notch receptors. It is expressed in the heart and pancreas, and to a lesser extent in various other tissues. DLL-1 functions to specifically activate the Notch-1 and Notch-2 receptors. The Notch signaling pathway regulates endothelial-cell differentiation, proliferation and apoptosis, and is essential for the development, maintenance and remodeling of the vascular system. DLL-1 suppresses differentiation of hematopoietic progenitor cells into the B-cell lineage while promoting differentiation to T-cell and NK cell precursors. Recombinant human sDLL-1 is a 57.0-60.0 kDa glycoprotein containing 522 amino-acid residues.
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基因ID
- 24772
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NCBI登录号
- NP_001029054
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OMIM
- 76496504
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UniProt
- Q9QZD1
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途径
- Notch Signaling, Stem Cell Maintenance
抗原
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