Persephin Protein (PSPN)
This Recombinant Persephin protein is expressed in 大肠杆菌（E. Coli）.
Quick Overview for Persephin Protein (PSPN) (ABIN2468967)
抗原
See all Persephin (PSPN) 蛋白
Persephin (PSPN)
蛋白类型
Recombinant
生物活性
Active
宿主
小鼠
资源
大肠杆菌（E. Coli）
纯度
< 98 % by SDS-PAGE gel and HPLC analyses.
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序列
- ALAGSCRLWS LTLPVAELGL GYASEEKVIF RYCAGSCPQE ARTQHSLVLA RLRGRGRAHG RPCCQPTSYA DVTFLDDQHH WQQLPQLSAA ACGCGG
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产品特性
- The ED50 was determined by its ability to stimulate proliferation of human thyroid carcinoma cells (TT cells) is < 0.1 ng/mL, corresponding to a specific activity of > 1 x 107 units/mg.
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内毒素水平
- Endotoxin level is less than 0.1 ng per μg (1 EU/μg).
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Persephin (PSPN) (AA 61-156) protein (His tag)
PSPN 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
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限制
- 仅限研究用
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状态
- Lyophilized
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注意事项
- As with any protein, exposing Persephin recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
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储存条件
- -20 °C
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储存方法
- The recombinant protein is stable for at least 2 years from date of receipt at -20 °C. Reconstituted Persephin is stable for at least 3 months when stored in working aliquots with a carrier protein at -20 °C.
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有效期
- 24 months
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- Persephin (PSPN)
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别名
- Persephin
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背景
- Persephin is a disulfide-linked homodimer neurotrophic factor structurally related to GDNF, Artemin, and Neurturin. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. Persephin signals through a multicomponent receptor system, composed of RET and one of four GFRα (α1-α4) receptors. The GFRα4 was first identified in chicken and was later shown to be the preferential binding subunit for Persephin. Persephin promotes the survival of ventral midbrain dompaminergic neurons and motor neurons after sciatic nerve oxotomy, and like GNDF, promotes ureteric bud branching. However, in contrast to GDNF and Neurturin, Persephin does not support survival of peripheral neurons. Recombinant murine Persephin is a disulfide-linked homodimer, composed of two 10.3 kDa polypeptide chains (96 total amino acid residues). Each chain contains seven conserved cysteine residues, one of which (Cys 63) is used for inter-chain disulfide bridging and the others are involved in intramolecular ring formation known as the cysteine knot configuration
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基因ID
- 19197
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NCBI登录号
- NP_032980
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OMIM
- 247269886
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UniProt
- O70300
抗原
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