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FGF2 Protein (AA 143-288)

This Recombinant FGF2 protein is expressed in 大肠杆菌(E. Coli) and has been mentioned in 2+ publications.
产品编号 ABIN2444057
发货至: 中国

Quick Overview for FGF2 Protein (AA 143-288) (ABIN2444057)

抗原

See all FGF2 蛋白
FGF2 (Fibroblast Growth Factor 2 (Basic) (FGF2))

蛋白类型

Recombinant

生物活性

Active

宿主

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资源

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大肠杆菌(E. Coli)

纯度

>95 % as determined by SDS-PAGE.
  • 产品特性

    AA 143-288

    序列

    AA 143-288

    产品特性

    This protein carries no "tag". The protein has a calculated MW of 16.5 kDa. The protein migrates as 17 kDa under reducing (R) condition (SDS-PAGE).

    内毒素水平

    Less than 1.0 EU per μg by the LAL method.
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  • 限制

    仅限研究用
  • 状态

    Lyophilized

    缓冲液

    PBS, pH 7.4

    注意事项

    Please avoid repeated freeze-thaw cycles.

    储存条件

    -20 °C

    储存方法

    Lyophilized Protein should be stored at -20 °C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20 °C or -70 °C. Avoid repeated freeze-thaw cycles.
  • Jiang, Liang, Li, Peng, Huang, Huang: "Basic fibroblast growth factor accelerates myelin debris clearance through activating autophagy to facilitate early peripheral nerve regeneration." in: Journal of cellular and molecular medicine, (2021) (PubMed).

    Wu, I-Shing Yu, Tsai, Shih, Hwang, Su, Chiang: "Defining minimum essential factors to derive highly pure human endothelial cells from iPS/ES cells in an animal substance-free system." in: Scientific reports, Vol. 5, pp. 9718, (2016) (PubMed).

  • 抗原

    FGF2 (Fibroblast Growth Factor 2 (Basic) (FGF2))

    别名

    FGF Basic

    背景

    FGF basic is a member of the FGF family of at least 23 related mitogenic proteins which show 35-60 % amino acid conservation. FGF acidic and basic, unlike the other members of the family, lack signal peptides and are apparently secreted by mechanisms other than the classical protein secretion pathway. FGF basic has been isolated from a number of sources, including neural tissue, pituitary, adrenal cortex, corpus luteum, and placenta. This factor contains four cysteine residues, but reduced FGF basic retains full biological activity, indicating that disulfide bonds are not required for this activity. bFGF is a critical component of human embryonic stem cell culture medium, the growth factor is necessary for the cells to remain in an undifferentiated state, although the mechanisms by which it does this are poorly defined. It has been demonstrated to induce gremlin expression which in turn is known to inhibit the induction of differentiation by bone morphogenetic proteins. It is necessary in mouse-feeder cell dependent culture systems, as well as in feeder and serum-free culture systems.

    分子量

    16.5 kDa

    途径

    RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, C21-Steroid Hormone Metabolic Process, Inositol Metabolic Process, Glycosaminoglycan Metabolic Process, Protein targeting to Nucleus, S100 Proteins
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