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IL-4 Protein (AA 25-153)

This Recombinant IL-4 protein is expressed in HEK-293 Cells and has been mentioned in 4+ publications.

SDS

Immobilized Human IL-4, Tag Free (ABIN2181318,ABIN3071738) at 5 μg/mL (100 μL/well)can bind Human IL-4 R alpha, Fc Tag (ABIN6731257,ABIN6809937) with a linear range of 1-20 ng/mL (Routinely tested). (IL-4 Protein (AA 25-153))

ELISA

Immobilized Human IL-4, Tag Free (ABIN2181318,ABIN3071738) at 5 μg/mL (100 μL/well) can bind Biotinylated Human IL-4 R alpha, Avitag,His Tag (ABIN4949031,ABIN4949032) with a linear range of 2-78 ng/mL (QC tested). (IL-4 Protein (AA 25-153))

ELISA

3 images

(4 references)

产品编号 ABIN2181318

发货至: 中国

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Quick Overview for IL-4 Protein (AA 25-153) (ABIN2181318)

抗原

See all IL-4 (IL4) 蛋白

IL-4 (IL4) (Interleukin 4 (IL4))

蛋白类型

Recombinant

生物活性

Active

宿主

人

资源

HEK-293 Cells

纯度

>90 % as determined by SDS-PAGE.

Discover our top product IL4 蛋白

产品特性

AA 25-153

品牌

ActiveMax®

序列

AA 25-153

产品特性

This protein carries no "tag". The protein has a calculated MW of 14.9 kDa. The protein migrates as 15 and 19 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

过滤

0.22 μm filtered

内毒素水平

Less than 0.1 EU per μg by the LAL method.
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Interleukin 4 (IL4) (AA 25-153) protein (His tag)
IL4 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Interleukin 4 (IL4) (AA 25-153) protein (His-Avi Tag,Biotin)
IL4 宿主: 人宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE

Interleukin 4 (IL4) (AA 25-153) protein (His-Avi Tag)
IL4 宿主: 人宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE

Interleukin 4 (IL4) (AA 23-140) (Active) protein
IL4 宿主: 小鼠宿主: CHO Cells Recombinant > 95 % as analyzed by SDS-PAGE and HPLC. Active

Interleukin 4 (IL4) (AA 25-153) (Active) protein
IL4 宿主: 人宿主: CHO Cells Recombinant > 95 % as analyzed by SDS-PAGE and HPLC. Active

Interleukin 4 (IL4) (AA 25-153) (Active) protein (His tag,AVI tag,Biotin)
IL4 宿主: 人宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active

Interleukin 4 (IL4) protein (His tag)
IL4 宿主: 小鼠宿主: 人细胞 Recombinant > 95 % as determined by SDS-PAGE

Interleukin 4 (IL4) (AA 25-153) (Active) protein (His tag)
IL4 宿主: 人宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA Active

Interleukin 4 (IL4) (AA 63-153) protein (GST tag)
IL4 宿主: 人宿主: 小麦胚 Recombinant WB, ELISA, AA, AP

Interleukin 4 (IL4) (AA 25-153) protein (mFc Tag)
IL4 宿主: 人宿主: Mammalian Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.

限制

仅限研究用
状态

Lyophilized

缓冲液

PBS, pH 7.4

注意事项

Please avoid repeated freeze-thaw cycles.

储存条件

-20 °C

储存方法

No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
Huang, Yi, Hu, Du, Wang, Ye, Su, Kijlstra, Yang: "Linoleic acid inhibits in vitro function of human and murine dendritic cells, CD4+T cells and retinal pigment epithelial cells." in: Graefe's archive for clinical and experimental ophthalmology, (2020) (PubMed).

He, Wang, Su, Deng, Ye, Huang, Yuan, Aize, Li, Yang: "Decreased expression of A20 is associated with ocular Behcet's disease (BD) but not with Vogt-Koyanagi-Harada (VKH) disease." in: The British journal of ophthalmology, Vol. 102, Issue 8, pp. 1167-1172, (2019) (PubMed).

Yi, Chang, Hu, Qiu, Wang, Cao, Yuan, Su, Zhou, Wang, Kijlstra, Yang: "Disabled-2 (DAB2) Overexpression Inhibits Monocyte-Derived Dendritic Cells' Function in Vogt-Koyanagi-Harada Disease." in: Investigative ophthalmology & visual science, Vol. 59, Issue 11, pp. 4662-4669, (2019) (PubMed).

Qiu, Yu, Zhu, Ye, Deng, Su, Cao, Yuan, Kijlstra, Yang: "Hypermethylation of Interferon Regulatory Factor 8 (IRF8) Confers Risk to Vogt-Koyanagi-Harada Disease." in: Scientific reports, Vol. 7, Issue 1, pp. 1007, (2017) (PubMed).
抗原

IL-4 (IL4) (Interleukin 4 (IL4))

别名

IL-4

背景

Interleukin-4, is a cytokine that induces differentiation of naive helper T cells (Th0 cells to Th2 cells). In the presence of IL-4 and IL-13, cytokines that are produced in a Th-2 type response, particularly during allergy and parasitic infections, macrophages become differentially activated, And this cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. Recently, researcher found that the cytokine IL-4 plays a key role in development of innate CD8+ T cells in the thymus of several gene-deficient mouse strains, including Itk, KLF2, CBP and Id3, without previous exposure to antigen.

分子量

15.0 kDa

途径

JAK/STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Proton Transport, Activated T Cell Proliferation