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FCGR2A Protein (AA 36-218) (His tag)

Name: FCGR2A Protein (AA 36-218) (His tag)
SKU: ABIN2180752
Availability: OutOfStock

This Recombinant FCGR2A protein is expressed in HEK-293 Cells and has been mentioned in 1 publication.

SDS-PAGE (SDS) image for Fc Fragment of IgG, Low Affinity IIa, Receptor (CD32) (FCGR2A) (AA 36-218) (Active) protein (His tag) (ABIN2180752) (FCGR2A Protein (AA 36-218) (His tag))

SDS

1 image

(1 reference)

产品编号 ABIN2180752

发货至: 中国

Quick Overview for FCGR2A Protein (AA 36-218) (His tag) (ABIN2180752)

抗原

See all FCGR2A 蛋白

FCGR2A (Fc Fragment of IgG, Low Affinity IIa, Receptor (CD32) (FCGR2A))

蛋白类型

Recombinant

生物活性

Active

宿主

人

资源

HEK-293 Cells

纯度

>95 % as determined by SDS-PAGE.

Discover our top product FCGR2A 蛋白

产品特性

AA 36-218

标记

This FCGR2A protein is labelled with His tag.

品牌

MABSol®

序列

AA 36-218

产品特性

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 21.2 kDa. The protein migrates as 29-32 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

过滤

0.22 μm filtered

内毒素水平

Less than 1.0 EU per μg by the LAL method.
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Fc Fragment of IgG, Low Affinity IIa, Receptor (CD32) (FCGR2A) (AA 36-218) protein (His-Avi Tag)
FCGR2A 宿主: 人宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Fc Fragment of IgG, Low Affinity IIa, Receptor (CD32) (FCGR2A) (AA 28-208) protein (His tag)
FCGR2A 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Fc Fragment of IgG, Low Affinity IIa, Receptor (CD32) (FCGR2A) (AA 36-218) protein (His-Avi Tag,Biotin)
FCGR2A 宿主: 人宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Fc Fragment of IgG, Low Affinity IIa, Receptor (CD32) (FCGR2A) (AA 36-218) protein (His-Avi Tag,Biotin)
FCGR2A 宿主: 人宿主: HEK-293 Cells Recombinant > 95 % by SEC-HPLC SDS, SEC-HPLC, SPR

Fc Fragment of IgG, Low Affinity IIa, Receptor (CD32) (FCGR2A) (AA 46-150) protein (GST tag)
FCGR2A 宿主: 人宿主: 小麦胚 Recombinant ELISA, WB, AP, AA

Fc Fragment of IgG, Low Affinity IIa, Receptor (CD32) (FCGR2A) protein (Fc Tag)
FCGR2A 宿主: 人宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.

Fc Fragment of IgG, Low Affinity IIa, Receptor (CD32) (FCGR2A) (Active) protein (His tag)
FCGR2A 宿主: 人宿主: CHO Cells Recombinant > 95 % as determined by reducing SDS-PAGE. Active

Fc Fragment of IgG, Low Affinity IIa, Receptor (CD32) (FCGR2A) (Active) protein (Fc Tag)
FCGR2A 宿主: 人宿主: HEK-293 Cells Recombinant > 90 % as determined by reducing SDS-PAGE. Active

Fc Fragment of IgG, Low Affinity IIa, Receptor (CD32) (FCGR2A) (AA 34-216) protein (His tag)
FCGR2A 宿主: 人宿主: 大肠杆菌（E. Coli） Recombinant > 90% by SDS-PAGE SDS

Fc Fragment of IgG, Low Affinity IIa, Receptor (CD32) (FCGR2A) (Active) protein (Biotin,His-Avi Tag)
FCGR2A 宿主: 人宿主: HEK-293 Cells Recombinant > 95 % as determined by reducing SDS-PAGE. Active

限制

仅限研究用
状态

Lyophilized

缓冲液

PBS, pH 7.4

注意事项

Please avoid repeated freeze-thaw cycles.

储存条件

-20 °C

储存方法

No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Simonov, Ivanov, Smolov, Abbasova, Piskunov, Poteryaev: "Control of therapeutic IgG antibodies galactosylation during cultivation process and its impact on IgG1/FcγR interaction and ADCC activity." in: Biologicals : journal of the International Association of Biological Standardization, Vol. 58, pp. 16-21, (2019) (PubMed).
抗原

FCGR2A (Fc Fragment of IgG, Low Affinity IIa, Receptor (CD32) (FCGR2A))

别名

Fc gamma RIIA / CD32a

背景

Receptors for the Fc region of IgG (Fc γ R) are members of the Ig superfamily that function in the activation or inhibition of immune responses. Three classes of human Fc γ Rs: RI (CD64), RII (CD32), and RIII (CD16), which generate multiple isoforms, are recognized. There are three genes for human Fcγ RII /CD32 (A, B, and C) and one for mouse Fcγ RII B (CD32B). CD32 is a low affinity receptor for IgG. The activating isoform, CD32A, is expressed on monocytes, neutrophils, platelets and dendritic cells. CD32A is expressed on many immune cell types (macrophage, neutrophil, eosinophils, platelets, dendritic cells and Langerhan cells), where inhibitory ITIM-bearing receptors may also be coexpressed and co-engaged by specific ligands. CD32A delivers an activating signal upon ligand binding, and results in the initiation of inflammatory responses including cytolysis, phagocytosis, degranulation and cytokine production. The responses can be modulated by signals from the coexpressed inhibitory receptors such as CD32B, and the strength of the signal is dependent on the ratio of expression of the activating and inhibitory receptors.

分子量

21.6 kDa