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Oncostatin M Protein (OSM) (AA 26-234)

This anti-Oncostatin M antibody (ABIN2018297) is a Escherichia coli (E. coli) antibody detecting Oncostatin M in . Suitable for Human.
产品编号 ABIN2018297
发货至: 中国

Quick Overview for Oncostatin M Protein (OSM) (AA 26-234) (ABIN2018297)

抗原

See all Oncostatin M (OSM) 蛋白
Oncostatin M (OSM)

蛋白类型

Recombinant

生物活性

Active

宿主

  • 25
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资源

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大肠杆菌(E. Coli)

纯度

> 95 % as analyzed by SDS-PAGE and HPLC.
  • 产品特性

    AA 26-234

    产品特性

    ED50 < 10 ng/mL, measured by a cell proliferation assay using TF-1 cells, corresponding to a specific activity of > 1x 10^5 units/mg.
    AA 26-234, expressed with an N-terminal Met.

    内毒素水平

    < 0.2 EU/μg, determined by LAL method.
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  • 限制

    仅限研究用
  • 状态

    Lyophilized

    溶解方式

    Reconstituted in ddH2O or PBS at 100 μg/mL.

    缓冲液

    Lyophilized after extensive dialysis against PBS.

    储存条件

    -80 °C

    储存方法

    Lyophilized recombinant human Oncostatin M(209 a.a.) (rhOSM) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, rhOSM should be stable up to 2 weeks at 4 °C or up to 3 months at -20 °C.

    有效期

    6 months
  • 抗原

    Oncostatin M (OSM)

    背景

    Oncostatin M (OSM) is a multifunctional cytokine, and belongs to Interleukin-6 (IL-6) subfamily, which also includes IL-11, leukemia inhibitory factor (LIF), ciliary neurotropic factor, cardiotrophin-1, and novel neurotropin-1. In vivo, OSM is secreted from activated T cells, monocytes, neutrophils, and endothelial cells. OSM is related to LIF, and shares a receptor with LIF in human. Human OSM can bind to gp130 and recruit OSM Receptor beta or LIF Receptor beta to form a ternary complex. OSM stimulates the growth of different types of cells, including megakaryocytes, fibroblasts, vascular endothelial cells, and T cells. OSM inhibits the proliferation of several cancer cell lines, such as solid tissue tumor cells, lung cancer cells, melanoma cells, and breast cancer cells. Recombinant human Oncostatin M(209 a.a.) (rhOSM) produced in E. coli is a single non-glycosylated polypeptide chain containing 210 amino acids. A fully biologically active molecule, rhOSM has a molecular mass of 23.8 kDa analyzed by reducing SDS-PAGE.
    Synonyms: OSM

    分子量

    23.8 kDa, observed by reducing SDS-PAGE.

    UniProt

    P13725

    途径

    JAK/STAT Signaling, Negative Regulation of Hormone Secretion
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