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NOG Protein (AA 20-232)

This Recombinant NOG protein is expressed in CHO Cells and has been mentioned in 1 publication.

2 μg of Noggin, Mouse was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie Blue staining. (NOG Protein (AA 20-232))

Noggin, Mouse inhibit BMP-4 induced alkaline phosphatase production in ATDC-5 cells in the presence of 10 ng/ml human BMP-4. (NOG Protein (AA 20-232))

2 images

(1 reference)

产品编号 ABIN2018288

发货至: 中国

Datasheet as PDF

Quick Overview for NOG Protein (AA 20-232) (ABIN2018288)

抗原

See all NOG 蛋白

NOG (Noggin (NOG))

蛋白类型

Recombinant

生物活性

Active

宿主

15
12
5
3
2
2
1
1

小鼠

资源

CHO Cells

纯度

> 95 % as analyzed by SDS-PAGE.

产品特性

AA 20-232

产品特性

ED50< 60 ng/mL, measured in a bioassay using ATDC5 cells in the presence of 10 ng/mL human BMP-4.

内毒素水平

< 0.2 EU/μg, determined by LAL method.
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Noggin (NOG) (AA 28-232) protein
NOG 宿主: 人宿主: CHO Cells Recombinant > 95 % as determined by Tris-Bis PAGE

Noggin (NOG) (AA 28-232) (Active) protein
NOG 宿主: 人宿主: CHO Cells Recombinant > 95 % as analyzed by SDS-PAGE. Active

Noggin (NOG) protein (His tag)
NOG 宿主: 小鼠宿主: 人细胞 Recombinant > 95 % as determined by reducing SDS-PAGE.

Noggin (NOG) (AA 28-232) protein (His tag)
NOG 宿主: 小鼠宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA

Noggin (NOG) (AA 28-232) protein (GST tag)
NOG 宿主: 人宿主: 小麦胚 Recombinant WB, ELISA, AA, AP

Noggin (NOG) protein (Fc Tag)
NOG 宿主: 人宿主: HEK-293 Cells Recombinant Greater than 95 % as determined by reducing SDS-PAGE.

Noggin (NOG) (AA 28-232) protein (Fc Tag)
NOG 宿主: 人宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.

Noggin (NOG) (Active) protein
NOG 宿主: 人宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS-PAGE Func Active

Noggin (NOG) (Active) protein
NOG 宿主: 小鼠宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS-PAGE Func Active

Noggin (NOG) (AA 28-232) protein (His-DYKDDDDK Tag)
NOG 宿主: 小鼠宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 90 % as determined by HPLC

限制

仅限研究用
状态

Lyophilized

溶解方式

Reconstituted in ddH2O or PBS at 100 μg/mL.

缓冲液

Lyophilized after extensive dialysis against PBS.

储存条件

-80 °C

储存方法

Lyophilized recombinant murine Nogginremains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, murine Nogginshould be stable up to 1 week at 4 °C or up to 2 months at -20 °C.

有效期

6 months
Bohnenpoll, Wittern, Mamo, Weiss, Rudat, Kleppa, Schuster-Gossler, Wojahn, Lüdtke, Trowe, Kispert: "A SHH-FOXF1-BMP4 signaling axis regulating growth and differentiation of epithelial and mesenchymal tissues in ureter development." in: PLoS genetics, Vol. 13, Issue 8, pp. e1006951, (2017) (PubMed).
抗原

NOG (Noggin (NOG))

别名

Noggin

背景

Noggin, also known as NOG, is a homodimeric glycoprotein that binds to and modulates the activity of TGF-beta family ligands. It is expressed in condensing cartilage and immature chondrocytes. Noggin antagonizes bone morphogenetic protein (BMP) activities by blocking epitopes on BMPs needed for binding to their receptors.Noggin has been shown to be involved in many developmental processes, such as neural tube formation and joint formation. During development, Noggin diffuses through extracellular matrices and forms morphogenic gradients that regulate cellular responses in a concentration-dependent manner.
Synonyms: NOG

分子量

29-31 kDa, observed by reducing SDS-PAGE.

UniProt

P97466

途径

Stem Cell Maintenance, Tube Formation

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