Neurotrophin 4 Protein (NTF4) (AA 80-209)
Quick Overview for Neurotrophin 4 Protein (NTF4) (AA 80-209) (ABIN2018283)
抗原
See all Neurotrophin 4 (NTF4) 蛋白蛋白类型
生物活性
宿主
资源
纯度
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产品特性
- AA 80-209
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产品特性
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ED50 <1 μg/mL, measured by a cell proliferation assay usingC6cells, corresponding to a specific activity of>1× 10^3 units/mg.
AA 80-209, expressed with an N-terminal Met. -
内毒素水平
- < 0.2 EU/μg, determined by LAL method.
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Neurotrophin 4 (NTF4) (AA 1-210) protein (GST tag)
NTF4 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Neurotrophin 4 (NTF4) (AA 81-210) proteinNTF4 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 85 % by SDS - PAGE SDS
Neurotrophin 4 (NTF4) (AA 82-210) protein (His tag)NTF4 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % SDS
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Reconstituted in 50 mM acetic acid or ddH2O at 100 μg/mL.
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缓冲液
- Lyophilized after extensive dialysis against 50 mM acetic acid.
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储存条件
- -80 °C
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储存方法
- Lyophilized recombinant mouse Neurotrophin-4 (rmNT-4) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, rmNT-4 remains stable up to 2 weeks at 4 °C or up to 3 months at -20 °C.
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有效期
- 6 months
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- Neurotrophin 4 (NTF4)
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别名
- Neurotrophin-4 (NT-4)
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背景
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Neurotrophin-4 (NT-4) is a small secreted cytokine, and belongs to the Neurotrophin (NT) family, which also includes Brain Derived Neurotropic Factor (BDNF), Nerve Growth Factor (NGF), and NT-3. NT family members are all derived from similar sized protein precursors, composed of N-terminal propeptides and C-terminal mature domains, which are separated by posttranslational proteolytic cleavage. NT-4 (along with NT-3) is foundin the brains of mammals . In vivo, NT-4 binds to the common receptor, p75NTR, and a tyrosine kinase receptor, TrkB. The heterotrimeric complex activates the NF-kappaB transcription factor. NT-4 is essential for the differentiation and wiring regulation of the central and peripheral nervous systems during development, and is related to important diseases including Alzheimer's.Recombinant mouse Neurotrophin-4 (rmNT-4) produced in E. coli is a noncovalently linked homodimer containing two non-glycosylated polypeptide chainsof 131 amino acids. A fully biologically active molecule, rmNT-4 has a molecular mass of 14.0 kDaanalyzed by reducing SDS-PAGE.
Synonyms: Neurotrophin-4, Neurotrophic 4/5 (NT-4/NT-5) -
分子量
- 14.0 kDa, observed by reducing SDS-PAGE.
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UniProt
- Q80VU4
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途径
- RTK signaling
抗原
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