IL-11 Protein (AA 22-199)
Quick Overview for IL-11 Protein (AA 22-199) (ABIN7477977)
抗原
See all IL-11 (IL11) 蛋白蛋白类型
生物活性
宿主
资源
纯度
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产品特性
- AA 22-199
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产品特性
- ED50 <5 ng/mL, measured in a proliferation assay using T11 cells.
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内毒素水平
- < 0.2 EU/μg, determined by LAL method.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Reconstituted in ddH2O or PBS at 100 μg/mL.
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缓冲液
- Lyophilized after extensive dialysis against PBS.
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储存条件
- -80 °C
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储存方法
- Lyophilized recombinant Human Interleukin-11 remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, Human Interleukin-11 should be stable up to 1 week at 4°C or up to 2 months at -20°C.
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有效期
- 6 months
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- IL-11 (IL11) (Interleukin 11 (IL11))
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别名
- Interleukin-11
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背景
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Interleukin-11 is a pleiotropic cytokine that was originally detected in the conditioned medium of an IL-1α-stimulated primate bone marrow stromal cell line (PU-34) as a mitogen for the IL-6-responsive mouse plasmacytoma cell line T11. IL-11 has multiple effects on both hematopoietic and non-hematopoietic cells. Many of the biological effects described for IL-11 overlap with those for IL-6. In vitro, IL-11 can synergize with IL-3, IL-4 and SCF to shorten the G0 period of early hematopoietic progenitors. IL-11 also enhances the IL-3-dependent megakaryocyte colony formation. IL-11 has been found to stimulate the T cell-dependent development of specific immunoglobulin-secreting B cells.
Synonyms: AGIF (Adipogenesis inhibitory factor) -
分子量
- 23 kDa, observed by reducing SDS-PAGE.
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UniProt
- P20809
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途径
- JAK/STAT Signaling, Negative Regulation of Hormone Secretion
抗原
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