Growth Hormone 1 Protein (GH1) (AA 27-217)
(3 references)Quick Overview for Growth Hormone 1 Protein (GH1) (AA 27-217) (ABIN2017922)
抗原
See all Growth Hormone 1 (GH1) 蛋白蛋白类型
生物活性
宿主
资源
纯度
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产品特性
- AA 27-217
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产品特性
- ED50 < 0.5 ng/mL, measured by a cell proliferation assay using Nb2-11 Cells, corresponding to a specific activity of > 2.0x 10^6 units/mg.
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内毒素水平
- < 0.2 EU/μg, determined by LAL method.
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Growth Hormone 1 (GH1) (Active) protein
GH1 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS-PAGE Func Active
Growth Hormone 1 (GH1) proteinGH1 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % as determined by SDS-PAGE
Growth Hormone 1 (GH1) (AA 1-217) protein (GST tag)GH1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Growth Hormone 1 (GH1) (Active) proteinGH1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % as determined by reducing SDS-PAGE. Active
Growth Hormone 1 (GH1) proteinGH1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant 98,00% SDS
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Reconstituted in ddH2O at 100 μg/mL.
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缓冲液
- Lyophilized after extensive dialysis against PBS.
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储存条件
- -80 °C
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储存方法
- Lyophilized recombinant human Growth Hormone (rhGH) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, rhGH should be stable up to 2 weeks at 4 °C or up to 3 months at -20 °C.
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有效期
- 6 months
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: "A novel peptide antagonist of the human growth hormone receptor." in: The Journal of biological chemistry, pp. 100588, (2021) (PubMed).
: "Growth Hormone Upregulates Mediators of Melanoma Drug Efflux and Epithelial-to-Mesenchymal Transition In Vitro and In Vivo." in: Cancers, Vol. 12, Issue 12, (2020) (PubMed).
: "Growth Hormone Receptor Knockdown Sensitizes Human Melanoma Cells to Chemotherapy by Attenuating Expression of ABC Drug Efflux Pumps." in: Hormones & cancer, Vol. 8, Issue 3, pp. 143-156, (2018) (PubMed).
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: "A novel peptide antagonist of the human growth hormone receptor." in: The Journal of biological chemistry, pp. 100588, (2021) (PubMed).
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- Growth Hormone 1 (GH1)
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别名
- Growth Hormone (GH)
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背景
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Growth Hormone (GH) is a member of the somatotropin/prolactin family which play an important role in growth control. The human GH cDNA encodes a 217 amino acid (aa), and the first 26 aa is a signal peptide. By alternative splicing, at least four isoforms of GH have been identified. The major role of GH in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. GH stimulates both the differentiation and proliferation of myoblasts, and also stimulates amino acid uptake and protein synthesis in muscle and other tissues.Recombinant human Growth Hormone (rhGH) produced in E. coli is a single non-glycosylated polypeptide chain containing 191 amino acids. A fully biologically active molecule, rhGH has a molecular mass of 22.1 kDa analyzed by reducing SDS-PAGE.
Synonyms: GH1, GH, GHN, GH-N, hGH-N,Pituitary growth hormone, Growth hormone 1, Somatotropin -
分子量
- 22.1 kDa, observed by reducing SDS-PAGE.
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UniProt
- P01241
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途径
- NF-kappaB Signaling, JAK/STAT Signaling, Intracellular Steroid Hormone Receptor Signaling Pathway, Peptide Hormone Metabolism, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Hormone Metabolic Process, Response to Growth Hormone Stimulus, Regulation of Hormone Biosynthetic Process
抗原
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