FGF6 Protein (AA 41-208)
This Recombinant FGF6 protein is expressed in 大肠杆菌（E. Coli）.
产品编号 ABIN2017827
发货至:
中国
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Quick Overview for FGF6 Protein (AA 41-208) (ABIN2017827)
抗原
See all FGF6 蛋白
FGF6
(Fibroblast Growth Factor 6 (FGF6))
蛋白类型
Recombinant
生物活性
Active
宿主
人
资源
大肠杆菌（E. Coli）
纯度
> 95 % as analyzed by SDS-PAGE and HPLC.
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产品特性
- AA 41-208
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产品特性
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ED50 < 2.5 ng/mL, measured by a cell proliferation assay using 3T3 cells in the presence 1 xg/mL heparin, corresponding to a specific activity of > 4x 10^5 units/mg.
AA 41-208, expressed with an N-terminal Met. -
内毒素水平
- < 0.2 EU/μg, determined by LAL method.
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Fibroblast Growth Factor 6 (FGF6) (AA 41-208) protein (His-IF2DI Tag)
FGF6 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Reconstituted in ddH2O at 100 μg/mL.
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缓冲液
- Lyophilized after extensive dialysis against PBS.
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储存条件
- -80 °C
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储存方法
- Lyophilized recombinant human Fibroblast Growth Factor-6 (rhFGF-6) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, rhFGF-6 remains stable up to 2 weeks at 4 °C or up to 3 months at -20 °C.
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有效期
- 6 months
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- FGF6 (Fibroblast Growth Factor 6 (FGF6))
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别名
- Fibroblast Growth Factor-6 (FGF-6)
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背景
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Fibroblast Growth Factor-6 (FGF-6) is a cytokine belonging to the heparin-binding FGF family, and is structurally related to other members of FGF family, particularly FGF-4. In vivo, FGF-6 exhibits an expression profile predominantly restricted tothe myogenic lineage, and it preferentially binds to two of the FGF receptors: FGFR1 and FGFR4. FGF-6 functions in muscle regeneration, myoblast proliferation and migration, and muscle differentiation in a dose-dependent manner. In vivo high concentration of recombinant FGF-6 up-regulates and down-regulates FGFR1 and FGFR4, respectively, as FGFR1 promotes the proliferation while FGFR4 promotes the differentiation in the muscle. Besides its dual function in muscle regeneration, FGF-6 may act as a regulator of bone metabolism as well.Recombinant human Fibroblast Growth Factor-6 (rhFGF-6) produced in E. coli is a single non-glycosylated polypeptide chain containing 169 amino acids. A fully biologically active molecule, rhFGF-6 has a molecular mass of 18.8 kDa analyzed by reducing SDS-PAGE.
Synonyms: Fibroblast Growth Factor-6, HBGF-6, HST-2 -
分子量
- 18.8 kDa, observed by reducing SDS-PAGE.
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UniProt
- P10767
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途径
- RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
抗原
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