FGF21 Protein (AA 29-209)
Quick Overview for FGF21 Protein (AA 29-209) (ABIN2017820)
抗原
See all FGF21 蛋白蛋白类型
生物活性
宿主
资源
纯度
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产品特性
- AA 29-209
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产品特性
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ED50 < 0.5 xg/mL, measured by a cell proliferation assay using NIH-3T3 cells in the presence of 1.25 xg/mL mouse Klotho and 10 xg/mL heparin, corresponding to a specific activity of > 2x 10^3 units/mg.
AA 29-209, expressed with an N-terminal Gly. -
内毒素水平
- < 0.2 EU/μg, determined by LAL method.
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Fibroblast Growth Factor 21 (FGF21) (AA 29-209) protein (mFc-Avi Tag)
FGF21 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Fibroblast Growth Factor 21 (FGF21) (AA 29-209) protein (His tag)FGF21 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Fibroblast Growth Factor 21 (FGF21) (AA 29-209) protein (mFc-Avi Tag,Biotin)FGF21 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Fibroblast Growth Factor 21 (FGF21) (AA 29-209) protein (His tag)FGF21 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Fibroblast Growth Factor 21 (FGF21) (AA 29-210) protein (His tag)FGF21 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Fibroblast Growth Factor 21 (FGF21) (Active) proteinFGF21 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS-PAGE Func Active
Fibroblast Growth Factor 21 (FGF21) (AA 29-208) protein (His tag)FGF21 宿主: 大鼠 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Fibroblast Growth Factor 21 (FGF21) (AA 29-209) protein (Fc Tag)FGF21 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Fibroblast Growth Factor 21 (FGF21) (AA 30-209) protein (GST tag)FGF21 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Reconstituted in ddH2O at 100 μg/mL.
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缓冲液
- Lyophilized after extensive dialysis against PBS.
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储存条件
- -80 °C
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储存方法
- Lyophilized recombinant human Fibroblast Growth Factor-21 (rhFGF-21) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, rhFGF-21 remains stable up to 2 weeks at 4 °C or up to 3 months at -20 °C.
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有效期
- 6 months
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- FGF21 (Fibroblast Growth Factor 21 (FGF21))
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别名
- Fibroblast Growth Factor-21 (FGF-21)
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背景
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Fibroblast Growth Factor-21 (FGF-21) is a metabolic cytokine belonging to the heparin-binding FGF family. Along with FGF-19/15 and FGF-23, FGF-21 is categorized as a member of the atypical FGF subfamily, as it must be complexed to the Klotho co-receptor in order to bind to the FGF receptors and activate the downstream signaling pathway. In vivo FGF-21 is expressed in liver, pancreas, adipose tissue, and skeletal muscle, and it plays a central role in the energy metabolism. The expression of FGF-21 is stimulated by free fatty acids and insulin resistant states and is correlated with whole-body insulin resistance. FGF-21 activates glucose uptake in adipocytes and increases insulin sensitivity, implicating it as a novel target with potential anti-diabetic properties.Recombinant human Fibroblast Growth Factor-21 (rhFGF-21) produced in E. coli is a single non-glycosylated polypeptide chain containing 182 amino acids. A fully biologically active molecule, rhFGF-21 has a molecular mass of 19.5 kDa analyzed by reducing SDS-PAGE.
Synonyms: Fibroblast Growth Factor-21, FGFL -
分子量
- 19.5 kDa, observed by reducing SDS-PAGE.
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UniProt
- Q9NSA1
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途径
- RTK signaling
抗原
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