FGF8 Protein (AA 23-204, Isoform A)
Quick Overview for FGF8 Protein (AA 23-204, Isoform A) (ABIN2017793)
抗原
See all FGF8 蛋白蛋白类型
生物活性
宿主
资源
纯度
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产品特性
- AA 23-204, Isoform A
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产品特性
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ED50 < 500 ng/mL, measured by a cell proliferation assay using 3T3 cells in the presence of 1 μg/mL of heparin, corresponding to a specific activity of > 2x 10^3 units/mg.
AA 23-204 (isoform a), expressed with an N-terminal Met. -
内毒素水平
- < 0.2 EU/μg, determined by LAL method.
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Fibroblast Growth Factor 8 (Androgen-Induced) (FGF8) (AA 23-215) (Active) protein
FGF8 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % by SDS-PAGE and HPLC analyses. Active
Fibroblast Growth Factor 8 (Androgen-Induced) (FGF8) (Active) proteinFGF8 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS-PAGE Func Active
Fibroblast Growth Factor 8 (Androgen-Induced) (FGF8) (AA 23-215) protein (His tag)FGF8 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Fibroblast Growth Factor 8 (Androgen-Induced) (FGF8) (AA 53-233) protein (His tag)FGF8 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Fibroblast Growth Factor 8 (Androgen-Induced) (FGF8) (Active) proteinFGF8 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % as determined by reducing SDS-PAGE. Active
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Reconstituted in ddH2O at 100 μg/mL.
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缓冲液
- Lyophilized after extensive dialysis against PBS.
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储存条件
- -80 °C
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储存方法
- Lyophilized recombinant human Fibroblast Growth Factor 8a (rhFGF-8a) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, rhFGF-8a remains stable up to 2 weeks at 4 °C or up to 3 months at -20 °C.
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有效期
- 6 months
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- FGF8 (Fibroblast Growth Factor 8 (Androgen-Induced) (FGF8))
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背景
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Fibroblast Growth Factor 8a (FGF-8a) is a cytokine belonging to the heparin-binding FGF family, which has at least 23 members. FGF-8 has 8 different isoforms, named FGF-8a through FGF-8h. Different FGF-8 isoforms have different affinities to the receptors, and thus participate in different signaling cascade pathways. FGF-8 has very widespread expression during embryonic development, and is an organizer and inducer for gastrulation, somitogenesis, morphogenesis, and limb induction. However, FGF-8 is also a potential oncogene: in normal adult cells, FGF-8 has very low expression, but FGF-8 is highly expressed in cancer cells of breast, prostate, and ovarian tumors. FGF-8 promotes tumor angiogenesis by increasing neovascularization, and induces osteoblastic differentiation. Recombinant human Fibroblast Growth Factor 8a (rhFGF-8a) produced inE. coli is a single non-glycosylated polypeptide chain containing 183 amino acids. A fully biologically active molecule, rhFGF-8a has a molecular mass of 21.3 kDa analyzed by reducing SDS-PAGE.
Synonyms: AIGFa, HBGF-8a -
分子量
- 21.3 kDa, observed by reducing SDS-PAGE.
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UniProt
- P55075
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途径
- RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Dopaminergic Neurogenesis
抗原
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