Complement C4 蛋白
This Native Complement C4 protein is expressed in Human.
产品编号 ABIN1880330
发货至:
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Quick Overview for Complement C4 蛋白 (ABIN1880330)
抗原
See all Complement C4 (C4) 蛋白
Complement C4 (C4)
(Complement 4 (C4))
蛋白类型
Native
宿主
人
资源
Human
纯度
> 90 % by SDS-PAGE
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纯化方法
- Purified
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- 10mM PBS (pH 7.4).
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储存条件
- 4 °C
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- Complement C4 (C4) (Complement 4 (C4))
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别名
- Complement C4
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背景
- Complement C4 encodes the basic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. In addition, this gene exists as a long form and a short form due to the presence or absence of a 6.4 kb endogenous HERV-K retrovirus in intron 9. [
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途径
- Complement System
抗原
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