IL-17 蛋白
This not_set IL-17 protein is expressed in 大肠杆菌（E. Coli）.
产品编号 ABIN1684755
发货至:
中国
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中国
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Quick Overview for IL-17 蛋白 (ABIN1684755)
抗原
See all IL-17 (IL17) 蛋白
IL-17 (IL17)
(Interleukin 17 (IL17))
生物活性
Active
宿主
小鼠
资源
大肠杆菌（E. Coli）
纯度
> 95 %, as determined by SDS-PAGE and HPLC
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特异性
- Optimized DNA sequence encoding Mouse Interleukin-17A mature chain was expressed in Escherichia Coli.
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产品特性
- Native Mouse Interleukin17A, generated by the proteolytic removal of the signal peptide and propeptide, the molecule has a calculated molecular mass of approximately 16kDa. Recombinant Mouse IL-17A is a disulfide-linked monodimeric protein consisting of 137 amino acid residue subunits, and migrates as an approximately 16kDa protein under reducing conditions in SDS-PAGE.
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过滤
- 0.2 μm filtered
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内毒素水平
- Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).
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说明
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The activity was measured by the ability to bind Human IL17RA in a functional ELISA assay with a linear range of 10-500 ng/mL. Complete precursor sequence shown, expressed chain highlighted
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
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缓冲液
- PBS solution pH 7.5.
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注意事项
- Avoid repeated freeze/thaw cycles.
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储存条件
- -20 °C
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储存方法
- The lyophilized protein is stable for at least years from date of receipt at -20 °C. Upon reconstitution, this cytokine can be stored in working aliquots at - 8 °C for one month, or at -20 °C for six months, with a carrier protein without detectable loss of activity.
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有效期
- 12-24 months
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- IL-17 (IL17) (Interleukin 17 (IL17))
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别名
- IL-17
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背景
- IL-33, a member of the IL-1 family, signals via a heterodimeric receptor complex consisting of ST2 and IL-1R accessory protein and triggers the activation of NF-B and all three MAPKs: p38, ERK1/2, and JNK1/2 in mast cells. IL-33 is expressed in multiple tissues and by several cell types such as dermal fibroblasts and small airway epithelial and bronchial smooth muscle cells. IL-33 activated IL-1-like signaling responses in mast cells and enhanced IL-5 and IL-13 production from murine Th2-polarized splenocytes.Moreover, it was found that both human and murine mast cells when stimulated in vitro with IL-33 produced a wide spectrum of cytokines and chemokines. In addition, IL-33 enhanced IL-4-driven Th2 cell responses and acted as a selective chemoattractant for Th2 cell recruitment.
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UniProt
- Q62386
抗原
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