IL-17 蛋白
-
- 抗原 See all IL-17 (IL17) 蛋白
- IL-17 (IL17) (Interleukin 17 (IL17))
- 蛋白类型
- Recombinant
- 生物活性
- Active
-
宿主
- 小鼠
-
资源
- 大肠杆菌（E. Coli）
- 原理
- Recombinant Mouse Interleukin-17/IL-17 Protein (Active)
- 序列
- Thr 22-Ala158
- 产品特性
- A DNA sequence encoding the mature form of mouse IL17a (Q62386) (Thr 22-Ala158) was expressed and purified.
- 纯度
- > 97 % as determined by SDS-PAGE
- Biological Activity Comment
- 1. Measured by its binding ability in a functional ELISA. 2. Immobilized recombinant mouse IL17a at 10 μg/mL (100 μl/well) can bind human IL17Ra-Fc2h with a linear range of 16-500 ng/mL.
- Top Product
- Discover our top product IL17 蛋白
-
-
- 限制
- 仅限研究用
-
- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
-
- 抗原
- IL-17 (IL17) (Interleukin 17 (IL17))
- 别名
- Interleukin-17/IL-17 (IL17 产品)
- 别名
- CTLA8 Protein, IL-17 Protein, IL-17A Protein, IL17 Protein, Ctla-8 Protein, Ctla8 Protein, Il17 Protein, ChIL-17 Protein, IL-17F Protein, IL17A Protein, CTLA-8 Protein, interleukin 17A Protein, IL17A Protein, Il17a Protein
- 背景
-
Background: IL17, also known as IL17a, is a cytokine belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. The IL-17 family of cytokines includes six members, IL-17/IL-17A, IL-17B, IL-17C, IL-17D, IL-17E/IL-25, and IL-17F, which are produced by multiple cell types. IL-17 regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
Synonym: Ctla-8,Ctla8,IL-17,IL-17A,Il17
- 分子量
- 15.5 kDa
- UniProt
- Q62386
-
