VEGFC 蛋白
Quick Overview for VEGFC 蛋白 (ABIN1589785)
抗原
See all VEGFC 蛋白蛋白类型
生物活性
宿主
资源
纯度
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原理
- VEGF-C
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序列
- DTVKLAAAHY NTEILKSIDN EWRKTQCMPR EVCIDVGKEF GAATNTFFKP PCVSVYRCGG CCNSEGLQCM NTSTGYLSKT LFEITVPLSQ GPKPVTISFA NHTSCRCMSK LDVYRQVHSI IHHHHHH
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特异性
- Chromosomal location:16p11
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产品特性
- Length (aa):127
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Vascular Endothelial Growth Factor C (VEGFC) (AA 103-227) protein (His-Avi Tag)
VEGFC 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Vascular Endothelial Growth Factor C (VEGFC) (AA 103-227) protein (His-Avi Tag,Biotin)VEGFC 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Vascular Endothelial Growth Factor C (VEGFC) (AA 1-419) protein (GST tag)VEGFC 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Vascular Endothelial Growth Factor C (VEGFC) (AA 112-227) protein (His tag)VEGFC 宿主: 人 宿主: Baculovirus infected Insect Cells Recombinant > 90% by SDS-PAGE SDS
Vascular Endothelial Growth Factor C (VEGFC) (AA 112-227), (full length) protein (GST tag)VEGFC 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant 90 % ELISA
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应用备注
- The biological activity was determined (i) by the ability to induce VEGFR-3/FLT-4 receptor phosphorylation in PAEC/VEGFR-3 cells and (ii) the VEGF-C-induced proliferation of primary human dermal lymphatic endothelial cells (HDLEC).
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说明
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Cytokines & Growth Factors
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- The lyophilized VEGF-C is soluble in water and most aqueous buffers. The lyophilized VEGF-C should be reconstituted in PBS or medium to a concentration not lower than 50 μg/mL.
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缓冲液
- 50 mM acetic acid
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C,-80 °C
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储存方法
- Lyophilized samples are stable for greater than six months at -20°C to -70°C. Reconstituted VEGF-C should be stored in working aliquots at -20°C. Avoid repeated freeze-thaw cycles!
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有效期
- 6 months
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- VEGFC (Vascular Endothelial Growth Factor C (VEGFC))
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别名
- VEGF-C
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背景
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VEGF-C, also known as Vascular Endothelial Growth Factor Related Protein (VRP), is a recently discovered VEGF growth factor family member that is most closely related to VEGF-D. The rat VEGF C cDNA encodes a pre-pro-protein of 416 amino acids residues. It is almost identical to the mouse VEGF-C protein. Similar to VEGF-D, VEGF-C has a VEGF homology domain spanning the middle third of the precursor molecule and long N- and C-terminal extensions. In adults, VEGF-C is highly expressed in heart, placenta, ovary and small intestine. Recombinant rat VEGF-C, lacking the N- and C-terminal extensions and containing only the middle VEGF homology domain, forms primarily non-covalently linked dimers. This protein is a ligand for both VEGFR-2/KDR and VEGFR-3/FLT-4. Since VEGFR-3 is strongly expressed in lymphatic endothelial cells, it has been postulated that VEGF-C is involved in the regulation of the growth and/or differentiation of lymphatic endothelium. Although recombinant rat VEGF-C is also a mitogen for vascular endothelial cells, it is much less potent than VEGF-A. The recombinant rat VEGF-C contains 127 amino acids residues and was fused to a His-tag (6x His) at the C-terminal end. As a result of glycosylation VEGF-C migrates as an 15-20 kDa protein in SDS-PAGE under reducing conditions.
Synonyms: vascular endothelial growth factor C, Vegfc -
分子量
- 15.0 - 20.0 kDa
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基因ID
- 114111
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NCBI登录号
- NM_053653, NP_446105
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UniProt
- O35757
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途径
- RTK signaling, Signaling Events mediated by VEGFR1 and VEGFR2
抗原
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