FGF4 蛋白
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北京 101111
Quick Overview for FGF4 蛋白 (ABIN1589633)
抗原
See all FGF4 蛋白蛋白类型
生物活性
宿主
资源
纯度
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原理
- Recombinant Human FGF-4 Protein
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序列
- APTAPNGTLE AELERRWESL VALSLARLPV AAQPKEAAVQ SGAGDYLLGI KRLRRLYCNV GIGFHLQALP DGRIGGAHAD TRDSLLELSP VERGVVSIFG VASRFFVAMS SKGKLYGSPF FTDECTFKEI LLPNNYNAYE SYKYPGMFIA LSKNGKTKKG NRVSPTMKVT HFLP RL
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特异性
- Chromosomal location:11q13.3
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产品特性
- Length (aa):177
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Fibroblast Growth Factor 4 (FGF4) protein
FGF4 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by reducing SDS-PAGE.
Fibroblast Growth Factor 4 (FGF4) (AA 71-206) protein (His tag)FGF4 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Fibroblast Growth Factor 4 (FGF4) (AA 30-202) protein (His-IF2DI Tag)FGF4 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Fibroblast Growth Factor 4 (FGF4) (AA 25-206) protein (His-IF2DI Tag)FGF4 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
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应用备注
- The biological activity was determined by the induction of proliferation in NHDF cells (Normal Human Dermal Fibroblasts).
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说明
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Cytokines & Growth Factors
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- PBS (sterile),We recommend a quick spin followed by reconstitution in water to a concentration of 0.1-1.0 mg/mL. This solution can then be diluted into other aqueous buffers and stored at 4 °C for 1 week or -20 °C for future use.
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缓冲液
- PBS
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注意事项
- Avoid repeated freeze-thaw cycles. We recommend a quick spin followed by reconstitution
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储存条件
- 4 °C,-20 °C
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储存方法
- The lyophilized protein is stable for a few weeks at room temperature, but best stored at -20°C. Reconstituted FGF-4 should be stored in working aliquots at -20°C. Avoid repeated freeze-thaw cycles.
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有效期
- 2-3 weeks
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- FGF4 (Fibroblast Growth Factor 4 (FGF4))
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别名
- FGF-4
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背景
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Synonyms: FGF4, HST, KFGF, HST-1, HSTF1, K-FGF, HBGF-4
Description: FGF-4 (fibroblast growth factor 4), also known as K-FGF (Kaposi's sarcoma associated FGF), is a 25 kDa secreted, heparin binding member of the FGF family. The human FGF-4 cDNA encodes 206 amino acids (aa) with a 33 aa signal sequence and a 173 aa mature protein with an FGF homology domain that contains a heparin binding region near the C terminus. Mature human FGF-4 shares a high aa identity with mouse, rat, canine and bovine FGF-4, respectively. The expression of FGF-4 and its receptors, FGF-R1c, -R2c, -R3c and R4, is spatially and temporally regulated during embryonic development. Its expression in the mouse trophoblast inner cell mass promotes expression of FGF-R2, and is required for maintenance of the trophectoderm and primitive endoderm. FGF-4 is proposed to play a physiologically relevant role in human embryonic stem cell self-renewal. It promotes stem cell proliferation, but may also aid differentiation depending on context and concentration, and is often included in embryonic stem cell media in-vitro. FGF-4 is mitogenic for fibroblasts and endothelial cells in-vitro and has autocrine transforming potential. It is a potent angiogenesis promoter in-vivo and has been investigated as therapy for coronary artery disease.
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分子量
- 19.7 kDa
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基因ID
- 2249
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NCBI登录号
- NM_002007, NP_001998
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UniProt
- P08620
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途径
- RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Stem Cell Maintenance
抗原
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