Flagellin Protein (FliC)
-
- 抗原 See all Flagellin (FliC) 蛋白
- Flagellin (FliC)
- 蛋白类型
- Native
-
宿主
- Salmonella typhimurium
-
资源
- Salmonella typhimurium
- 原理
- Flagellin (high purity)
- 特异性
- Binds to human and mouse TLR5 (Toll-like receptor 5).
- 交叉反应
- 人, 小鼠
- 纯度
- high purity
- 内毒素水平
- <0.001EU/μg purified protein (LAL test, Lonza).
- Biological Activity Comment
- Activation of TLR5 in human epithelial cell assays based on NF-kappaB luciferase fusions, on expression of IL-8 (CXCL8), CCL20, inducible nitric oxide synthase, beta-defensin 2 and matrilysin (MMP-7). Maturation of dendritic cells in in vitro and in vivo assays. Adjuvant activity on foreign antigens delivered by subcutaneous and intranasal routes in mice. TLR5 can be stimulated in vitro by Flagellin (high Purity) at a concentration of 5-50ng /ml and in vivo at a starting concentration of 0.1-1μg /mouse.
- Top Product
- Discover our top product FliC 蛋白
-
想要此Protein的其他选项吗?
!探索我们的预定义定制蛋白和定制蛋白服务!Product表达系统ConjugateOrigin价格从表达系统 RabbitConjugateOrigin Discosoma价格从 3,390.66 ¥表达系统 Guinea PigConjugateOrigin Rabbit价格从 3,390.66 ¥表达系统 RabbitConjugateOrigin Cow, Human, Mouse, Pig, Rabbit, Rat价格从 1,093.86 ¥表达系统 RabbitConjugateOrigin Cow, Human, Mouse, Pig, Rat价格从 5,693.28 ¥表达系统 RabbitConjugateOrigin Human, Mouse, Rat价格从 3,240.03 ¥表达系统 RabbitConjugateOrigin Human, Monkey, Mouse, Pig, Rat, Sheep价格从 3,240.03 ¥表达系统 RabbitConjugateOrigin Horse, Human, Mouse, Rabbit, Rat价格从 3,240.03 ¥表达系统 RabbitConjugateOrigin Coral价格从 3,749.94 ¥表达系统 GoatConjugateOrigin Dog, Human, Monkey, Mouse, Rat价格从 4,721.57 ¥表达系统 RabbitConjugateOrigin Human价格从 12,716.37 ¥您的项目需要进一步定制吗?联系我们,了解我们的定制蛋白解决方案
-
-
- 限制
- 仅限研究用
-
- 状态
- Lyophilized
- 溶解方式
- 0.1 mg/mL after reconstitution
- 浓度
- 0.1 mg/mL
- 缓冲液
- Contains PBS.
- 注意事项
- After reconstitution, prepare aliquots and store at -20 °C.Avoid freeze/thaw cycles.Centrifuge lyophilized vial before opening and reconstitution.
- 储存条件
- 4 °C,-20 °C
- 储存方法
-
Short Term Storage: +4°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 6 months after receipt when stored at -20°C.
- 有效期
- 6 months
-
- 抗原
- Flagellin (FliC)
- 别名
- Flagellin (FliC 产品)
- 背景
-
FliC
Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. It activates the innate immune system through the receptor Toll-like Receptor 5 (TLR5) and the intracellular protein NLRC4 (NLR family CARD domain-containing protein 4).
- 分子量
- ~54kDa (SDS-PAGE)
- UniProt
- P06179
- 途径
- Inflammasome
-