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HMGB1 Protein (AA 1-215) (GST tag)

Name: HMGB1 Protein (AA 1-215) (GST tag)
SKU: ABIN1306797
Availability: OutOfStock

This Recombinant HMGB1 protein is expressed in 小麦胚 and has been mentioned in 28+ publications.

Image no. 1 for High Mobility Group Box 1 (HMGB1) (AA 1-215) protein (GST tag) (ABIN1306797) (HMGB1 Protein (AA 1-215) (GST tag))

1 image

(28 references)

产品编号 ABIN1306797

发货至: 中国

Quick Overview for HMGB1 Protein (AA 1-215) (GST tag) (ABIN1306797)

抗原

See all HMGB1 蛋白

HMGB1 (High Mobility Group Box 1 (HMGB1))

蛋白类型

Recombinant

宿主

人

资源

小麦胚

应用范围

Western Blotting (WB), ELISA, Antibody Array (AA), Affinity Purification (AP)

产品特性

AA 1-215

标记

This HMGB1 protein is labelled with GST tag.

原理

HMGB1 (Human) Recombinant Protein (P01)

序列

MGKGDPKKPR GKMSSYAFFV QTCREEHKKK HPDASVNFSE FSKKCSERWK TMSAKEKGKF EDMAKADKAR YEREMKTYIP PKGETKKKFK DPNAPKRPPS AFFLFCSEYR PKIKGEHPGL SIGDVAKKLG EMWNNTAADD KQPYEKKAAK LKEKYEKDIA AYRAKGKPDA AKKGVVKAEK SKKKKEEEED EEDEEDEEEE EDEEDEDEEE DDDDE

产品特性

Human HMGB1 full-length ORF ( AAH03378.1, 1 a.a. - 215 a.a.) recombinant protein with GST-tag at N-terminal.

纯化方法

in vitro wheat germ expression system
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High Mobility Group Box 1 (HMGB1) (AA 1-215) protein (His tag)
HMGB1 宿主: 人宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

High Mobility Group Box 1 (HMGB1) (AA 1-215) protein (His tag,Biotin)
HMGB1 宿主: 人宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

High Mobility Group Box 1 (HMGB1) (Non-oxidizable) (Active) protein
HMGB1 宿主: 人, 小鼠, 大鼠宿主: 大肠杆菌（E. Coli） Recombinant > 95 % Act, CA Active

High Mobility Group Box 1 (HMGB1) (Active) protein
HMGB1 宿主: 人, 小鼠, 大鼠宿主: 大肠杆菌（E. Coli） Recombinant > 95 % Act, CA Active

High Mobility Group Box 1 (HMGB1) (AA 1-90) protein (GST tag)
HMGB1 宿主: 人宿主: 小麦胚 Recombinant WB, ELISA, AA, AP

High Mobility Group Box 1 (HMGB1) (AA 1-215) protein
HMGB1 宿主: 人宿主: Baculovirus Recombinant > 90 % pure SDS

High Mobility Group Box 1 (HMGB1) (Active) protein (Fc Tag)
HMGB1 宿主: 小鼠宿主: HEK-293 Cells Recombinant > 85 % as determined by SDS-PAGE Active

High Mobility Group Box 1 (HMGB1) (AA 1-215) protein (His tag)
HMGB1 宿主: 人宿主: Hi-5 Cells Recombinant > 90 % by SDS - PAGE SDS

High Mobility Group Box 1 (HMGB1) protein
HMGB1 宿主: 人宿主: 大肠杆菌（E. Coli） Recombinant > 95 % as determined by reducing SDS-PAGE.

High Mobility Group Box 1 (HMGB1) (AA 24-215) protein (His tag)
HMGB1 宿主: 大鼠宿主: 大肠杆菌（E. Coli） Recombinant >90 % (SDS-PAGE)

应用备注

Optimal working dilution should be determined by the investigator.

说明

Preparation method: in vitro, wheat germ expression system
Product Quality tested by: 12.5% SDS-PAGE Stained with Coomassie Blue.

限制

仅限研究用
缓冲液

50 mM Tris-HCI, 10 mM reduced Glutathione, pH =8.0 in the elution buffer.

注意事项

Aliquot to avoid repeated freezing and thawing.

储存条件

-80 °C

储存方法

Best use within three months from the date of receipt of this protein.
Yang, Lee, Song, Bae: "Ameliorative effect of a rarely occurring C-methylrotenoid on HMGB1-induced septic responses in vitro and in vivo." in: Biochemical pharmacology, Vol. 110-111, pp. 58-70, (2016) (PubMed).

Fang, Jiang: "IL-1β/HMGB1 signalling promotes the inflammatory cytokines release via TLR signalling in human intervertebral disc cells." in: Bioscience reports, Vol. 36, Issue 5, (2016) (PubMed).

Min, Ku, Park, Park, Lee, Bae: "Anti-septic effects of pelargonidin on HMGB1-induced responses in vitro and in vivo." in: Archives of pharmacal research, Vol. 39, Issue 12, pp. 1726-1738, (2016) (PubMed).

Lee, Park, Kwak, Kim, Na, Bae: "PEGylated lysozymes with anti-septic effects in human endothelial cells and in mice." in: Biochemical and biophysical research communications, Vol. 459, Issue 4, pp. 662-7, (2015) (PubMed).

Kwak, Ku, Kang, Baek, Bae: "Methylthiouracil, a new treatment option for sepsis." in: Vascular pharmacology, (2015) (PubMed).

Tuan, Lee, Oh, Kulkarni, Gény, Jung, Kang, Bae, Na: "Flavanones and Chromones from Salicornia herbacea Mitigate Septic Lethality via Restoration of Vascular Barrier Integrity." in: Journal of agricultural and food chemistry, Vol. 63, Issue 46, pp. 10121-30, (2015) (PubMed).

Lee, Ku, Bae: "Factor Xa inhibits HMGB1-induced septic responses in human umbilical vein endothelial cells and in mice." in: Thrombosis and haemostasis, Vol. 112, Issue 4, pp. 757-69, (2014) (PubMed).

Ku, Lee, Kim, Bae: "Anti-septic effects of pellitorine in HMGB1-induced inflammatory responses in vitro and in vivo." in: Inflammation, Vol. 37, Issue 2, pp. 338-48, (2014) (PubMed).

Ku, Kim, Bae: "Vascular barrier protective effects of piperlonguminine in vitro and in vivo." in: Inflammation research : official journal of the European Histamine Research Society ... [et al.], Vol. 63, Issue 5, pp. 369-79, (2014) (PubMed).

Lee, Ku, Yoo, Song, Bae: "Andrographolide inhibits HMGB1-induced inflammatory responses in human umbilical vein endothelial cells and in murine polymicrobial sepsis." in: Acta physiologica (Oxford, England), Vol. 211, Issue 1, pp. 176-87, (2014) (PubMed).

Klawitter, Hakozaki, Kobayashi, Krupkova, Quero, Ospelt, Gay, Hausmann, Liebscher, Meier, Sekiguchi, Konno, Boos, Ferguson, Wuertz: "Expression and regulation of toll-like receptors (TLRs) in human intervertebral disc cells." in: European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, Vol. 23, Issue 9, pp. 1878-91, (2014) (PubMed).

Kwak, Ku, Han, Bae: "Vascular barrier protective effects of baicalin, baicalein and wogonin in vitro and in vivo." in: Toxicology and applied pharmacology, Vol. 281, Issue 1, pp. 30-38, (2014) (PubMed).

Yang, Ku, Lee, Lee, Lee, Song, Bae: "Barrier protective effects of rosmarinic acid on HMGB1-induced inflammatory responses in vitro and in vivo." in: Journal of cellular physiology, Vol. 228, Issue 5, pp. 975-82, (2013) (PubMed).

Lee, Ku, Kim, Bae: "Emodin-6-O-?-D-glucoside inhibits HMGB1-induced inflammatory responses in vitro and in vivo." in: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, Vol. 52, pp. 97-104, (2013) (PubMed).

Lee, Ku, Kim, Lee, Bae: "Inhibitory effects of epi-sesamin on HMGB1-induced vascular barrier disruptive responses in vitro and in vivo." in: Toxicology and applied pharmacology, Vol. 267, Issue 3, pp. 201-8, (2013) (PubMed).

Lee, Ku, Lee, Bae: "Anti-septic effects of glyceollins in HMGB1-induced inflammatory responses in vitro and in vivo." in: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, Vol. 63, pp. 1-8, (2013) (PubMed).

Bae: "Effects of lower concentration thrombin on high-mobility group box 1 protein-mediated inflammatory responses." in: Inflammation, Vol. 35, Issue 3, pp. 1078-86, (2012) (PubMed).

Kim, Ku, Bae: "Inhibitory effects of kaempferol-3-O-sophoroside on HMGB1-mediated proinflammatory responses." in: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, Vol. 50, Issue 3-4, pp. 1118-23, (2012) (PubMed).

Yang, Lee, Ku, Song, Bae: "Anti-inflammatory activities of oleanolic acid on HMGB1 activated HUVECs." in: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, Vol. 50, Issue 5, pp. 1288-94, (2012) (PubMed).

Lee, Ku, Bae, Bae: "Inhibitory effects of lycopene on HMGB1-mediated pro-inflammatory responses in both cellular and animal models." in: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, Vol. 50, Issue 6, pp. 1826-33, (2012) (PubMed).

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抗原

HMGB1 (High Mobility Group Box 1 (HMGB1))

别名

HMGB1

背景

Full Gene Name: high-mobility group box 1
Synonyms: DKFZp686A04236,HMG1,HMG3,SBP-1

基因ID

3146

途径

p53 Pathway, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Toll-Like Receptors Cascades, Smooth Muscle Cell Migration, Inflammasome