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HMGB1 Protein (BoxA Domain)

HMGB1 宿主: 人, 小鼠 宿主: 大肠杆菌(E. Coli) Recombinant > 98 % Act, CA Active
产品编号 ABIN1176814
发货至: 中国
  • 抗原 See all HMGB1 蛋白
    HMGB1 (High Mobility Group Box 1 (HMGB1))
    蛋白类型
    Recombinant
    生物活性
    Active
    产品特性
    BoxA Domain
    宿主
    • 26
    • 8
    • 6
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    人, 小鼠
    资源
    • 21
    • 12
    • 9
    • 2
    • 1
    • 1
    • 1
    大肠杆菌(E. Coli)
    应用范围
    Activation (Act), Cellular Assay (CA)
    序列
    MGKGDPKKPR GKMSSYAFFV QTCREEHKKK HPDASVNFSE FSKKCSERWK TMSAKEKGKF EDMAKADKAR YEREMKTYIP PKGETKKKF
    产品特性
    BoxA is an antagonist for HMGB1 and appears to inhibit all its activities, depending from all receptors. Injection of 600 µg BoxA in the mouse protects against sepsis in a peritonitis model and from hepatitis in a mouse model of HBV infection (Sitia et al 2007). BoxA (10 µg/mL) inhibits maturation, survival and Th1 differentiation of dendritic cells and T cell proliferation.It contains only trace amounts of LPS (<0.4 ng/mg protein), and it is tested for the ability to inhibit the chemotactic activity of HMGB1 on fibroblasts.
    纯化方法
    Purified
    纯度
    > 98 %
    内毒素水平
    The purified protein is free from LPS (Cambrex Limulus Amoebocyte Assay QCL-1000, <0.4 ng LPS per mg protein).
    Top Product
    Discover our top product HMGB1 蛋白
  • 限制
    仅限研究用
  • 状态
    Lyophilized
    缓冲液
    50 mM HEPES-Na pH 7.9, 500 mM NaCl, 0.5 mM DTT.
    注意事项
    The product is resistant to repeated freezing and thawing.
    储存条件
    -20 °C
  • Maroso, Balosso, Ravizza, Liu, Aronica, Iyer, Rossetti, Molteni, Casalgrandi, Manfredi, Bianchi, Vezzani: "Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures." in: Nature medicine, Vol. 16, Issue 4, pp. 413-9, (2010) (PubMed).

  • 抗原
    HMGB1 (High Mobility Group Box 1 (HMGB1))
    别名
    High-mobility group protein B1 (HMGB1) (HMGB1 产品)
    别名
    HMG1 Protein, HMG3 Protein, SBP-1 Protein, DEF Protein, HMG-1 Protein, Hmg1 Protein, amphoterin Protein, p30 Protein, hmgb1 Protein, ik:tdsubc_1a5 Protein, wu:fb23c02 Protein, xx:tdsubc_1a5 Protein, zgc:56110 Protein, zgc:77104 Protein, hmg-1 Protein, hmg3 Protein, sbp-1 Protein, hmg1 Protein, HMGB1 Protein, Ac2-008 Protein, high mobility group box 1 Protein, high-mobility group box 1 Protein, high mobility group box 1a Protein, high mobility group box 1 L homeolog Protein, high mobility group protein B1 Protein, HMGB1 Protein, Hmgb1 Protein, hmgb1 Protein, hmgb1a Protein, hmgb1.L Protein, LOC100359149 Protein
    背景
    BoxA is one of the highly conserved DNA binding domains of HMGB1 protein. It consists of 89 amino acids and has a calculated molecular mass of approximately 10.4 kDa. The sequence of BoxA is totally identical in human and mouse.
    分子量
    approximately 10.4 kDa
    途径
    p53 Pathway, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Toll-Like Receptors Cascades, Smooth Muscle Cell Migration, Inflammasome
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