HMGB1 Protein (BoxA Domain)
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- 抗原 See all HMGB1 蛋白
- HMGB1 (High Mobility Group Box 1 (HMGB1))
- 蛋白类型
- Recombinant
- 生物活性
- Active
- 产品特性
- BoxA Domain
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宿主
- 人, 小鼠
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资源
- 大肠杆菌(E. Coli)
- 应用范围
- Activation (Act), Cellular Assay (CA)
- 序列
- MGKGDPKKPR GKMSSYAFFV QTCREEHKKK HPDASVNFSE FSKKCSERWK TMSAKEKGKF EDMAKADKAR YEREMKTYIP PKGETKKKF
- 产品特性
- BoxA is an antagonist for HMGB1 and appears to inhibit all its activities, depending from all receptors. Injection of 600 µg BoxA in the mouse protects against sepsis in a peritonitis model and from hepatitis in a mouse model of HBV infection (Sitia et al 2007). BoxA (10 µg/mL) inhibits maturation, survival and Th1 differentiation of dendritic cells and T cell proliferation.It contains only trace amounts of LPS (<0.4 ng/mg protein), and it is tested for the ability to inhibit the chemotactic activity of HMGB1 on fibroblasts.
- 纯化方法
- Purified
- 纯度
- > 98 %
- 内毒素水平
- The purified protein is free from LPS (Cambrex Limulus Amoebocyte Assay QCL-1000, <0.4 ng LPS per mg protein).
- Top Product
- Discover our top product HMGB1 蛋白
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- 50 mM HEPES-Na pH 7.9, 500 mM NaCl, 0.5 mM DTT.
- 注意事项
- The product is resistant to repeated freezing and thawing.
- 储存条件
- -20 °C
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Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures." in: Nature medicine, Vol. 16, Issue 4, pp. 413-9, (2010) (PubMed).
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Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures." in: Nature medicine, Vol. 16, Issue 4, pp. 413-9, (2010) (PubMed).
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- 抗原
- HMGB1 (High Mobility Group Box 1 (HMGB1))
- 别名
- High-mobility group protein B1 (HMGB1) (HMGB1 产品)
- 别名
- HMG1 Protein, HMG3 Protein, SBP-1 Protein, DEF Protein, HMG-1 Protein, Hmg1 Protein, amphoterin Protein, p30 Protein, hmgb1 Protein, ik:tdsubc_1a5 Protein, wu:fb23c02 Protein, xx:tdsubc_1a5 Protein, zgc:56110 Protein, zgc:77104 Protein, hmg-1 Protein, hmg3 Protein, sbp-1 Protein, hmg1 Protein, HMGB1 Protein, Ac2-008 Protein, high mobility group box 1 Protein, high-mobility group box 1 Protein, high mobility group box 1a Protein, high mobility group box 1 L homeolog Protein, high mobility group protein B1 Protein, HMGB1 Protein, Hmgb1 Protein, hmgb1 Protein, hmgb1a Protein, hmgb1.L Protein, LOC100359149 Protein
- 背景
- BoxA is one of the highly conserved DNA binding domains of HMGB1 protein. It consists of 89 amino acids and has a calculated molecular mass of approximately 10.4 kDa. The sequence of BoxA is totally identical in human and mouse.
- 分子量
- approximately 10.4 kDa
- 途径
- p53 Pathway, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Toll-Like Receptors Cascades, Smooth Muscle Cell Migration, Inflammasome
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