PPM1A Protein (AA 2-382) (His tag)
Quick Overview for PPM1A Protein (AA 2-382) (His tag) (ABIN1097374)
抗原
See all PPM1A 蛋白蛋白类型
宿主
资源
纯度
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产品特性
- AA 2-382
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标记
- This PPM1A protein is labelled with His tag.
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原理
- Recombinant Human Protein Phosphatase 1A/PPM1A (C-6His)
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序列
- MGAFLDKPKM EKHNAQGQGN GLRYGLSSMQ GWRVEMEDAH TAVIGLPSGL ESWSFFAVYD GHAGSQVAKY CCEHLLDHIT NNQDFKGSAG APSVENVKNG IRTGFLEIDE HMRVMSEKKH GADRSGSTAV GVLISPQHTY FINCGDSRGL LCRNRKVHFF TQDHKPSNPL EKERIQNAGG SVMIQRVNGS LAVSRALGDF DYKCVHGKGP TEQLVSPEPE VHDIERSEED DQFIILACDG IWDVMGNEEL CDFVRSRLEV TDDLEKVCNE VVDTCLYKGS RDNMSVILIC FPNAPKVSPE AVKKEAELDK YLECRVEEII KKQGEGVPDL VHVMRTLASE NIPSLPPGGE LASKRNVIEA VYNRLNPYKN DDTDSTSTDD MWLEHHHHHH
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产品特性
- Recombinant Human Protein Phosphatase 1A/PPM1A is produced with our E. coli expression system. The target protein is expressed with sequence (Gly2-Trp382) of Human PPM1A.
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过滤
- 0.2 μm filtered
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内毒素水平
- Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test
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Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A (PPM1A) (AA 1-382) protein (GST tag)
PPM1A 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A (PPM1A) protein (His tag)PPM1A 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant > 98 % as determined by SDS-PAGE
Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A (PPM1A) (Transcript Variant 1) protein (His tag)PPM1A 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A (PPM1A) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)PPM1A 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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限制
- 仅限研究用
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状态
- Liquid
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溶解方式
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It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles. -
缓冲液
- Supplied as a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.
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注意事项
- Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
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储存条件
- -80 °C
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储存方法
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Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles. -
有效期
- 6 months
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- PPM1A (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A (PPM1A))
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别名
- Protein Phosphatase 1A/PPM1A
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背景
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Protein Phosphatase 1A (PPM1A) is a member of the PP2C family of Ser/Thr protein phosphatases which are known to be negative regulators of cell stress response pathways. PPM1A has a broad specificity. PPM1A negatively regulates the activities of MAP kinases and MAP kinase kinases. Also, it negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. In addition, PPM1A can dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control.
Alternative Names: Protein Phosphatase 1A, Protein Phosphatase 2C Isoform Alpha, PP2C-Alpha, Protein Phosphatase IA, PPM1A, PPPM1A -
分子量
- 43.5 kDa
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UniProt
- P35813
抗原
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