Interleukin 17a Protein (AA 20-155)
Quick Overview for Interleukin 17a Protein (AA 20-155) (ABIN1096903)
抗原
See all Interleukin 17a (IL17A) 蛋白蛋白类型
生物活性
宿主
资源
应用范围
纯度
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产品特性
- AA 20-155
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原理
- Recombinant Human Interleukin-17A/IL-17A
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序列
- MIVKAGITIP RNPGCPNSED KNFPRTVMVN LNIHNRNTNT NPKRSSDYYN RSTSPWNLHR NEDPERYPSV IWEAKCRHLG CINADGNVDY HMNSVPIQQE ILVLRREPPH CPNSFRLEKI LVSVGCTCVT PIVHHVA
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产品特性
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ED50 is approximately 2 ng/mL as determined by the dose-dependent induction of IL-6 in primary human foreskin fibroblasts.
Specific Activity of 5 x 10 5 IU/mg. -
过滤
- 0.2 μm filtered
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内毒素水平
- Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test
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Interleukin 17A (IL17A) (AA 24-155) protein (His tag)
IL17A 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 17A (IL17A) (AA 24-155) protein (His-Avi Tag,Biotin)IL17A 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Interleukin 17A (IL17A) (AA 24-155) protein (His-Avi Tag)IL17A 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 92 % as determined by HPLC
Interleukin 17A (IL17A) (AA 26-158) protein (His-Avi Tag,Biotin)IL17A 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Interleukin 17A (IL17A) (Active) protein (His tag)IL17A 宿主: Cynomolgus 宿主: 人细胞 Recombinant >95 % as determined by reducing SDS-PAGE. Active
Interleukin 17A (IL17A) (Active) protein (His tag)IL17A 宿主: 小鼠 宿主: 人细胞 Recombinant > 95 % as determined by SDS-PAGE Active
Interleukin 17A (IL17A) (AA 26-158) protein (His-Avi Tag)IL17A 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Interleukin 17A (IL17A) (AA 24-155) (Active) protein (His tag)IL17A 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Interleukin 17A (IL17A) (AA 24-155) (Active) protein (His tag,AVI tag,Biotin)IL17A 宿主: 人 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Interleukin 17A (IL17A) (AA 24-155) protein (His tag)IL17A 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses ELISA, WB
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
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It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles. -
缓冲液
- Lyophilized from a 0.2 μm filtered solution of 20 mM PB, pH 7.4.
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注意事项
- Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
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储存条件
- 4 °C/-20 °C/-80 °C
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储存方法
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Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Interleukin 17a (IL17A) (Interleukin 17A (IL17A))
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别名
- Interleukin-17A/IL-17A
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背景
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Recombinant Human Interleukin-17A/IL-17A produced in E. coli is a single non-glycosylated polypeptide chain containing 133 AAs with a molecular mass of 15,256 Daltons.
Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. As IL-17 shares properties with IL-1 and TNF-α, it may induce joint inflammation and bone and cartilage destruction. This cytokine is found in synovial fluids of patients with rheumatoid arthritis, and produced by rheumatoid arthritis synovium. It increases IL-6 production, induces collagen degradation and decreases collagen synthesis by synovium and cartilage and proteoglycan synthesis in cartilage. IL-17 is also able to increase bone destruction and reduce its formation. Blocking of interleukin-17 with specific inhibitors provides a protective inhibition of cartilage and bone degradation. -
分子量
- 15.26 kDa
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UniProt
- Q16552
抗原
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