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HMOX1 Protein (AA 1-261)

This Recombinant HMOX1 protein is expressed in 大肠杆菌(E. Coli).
产品编号 ABIN1690888
发货至: 中国

Quick Overview for HMOX1 Protein (AA 1-261) (ABIN1690888)

抗原

See all HMOX1 蛋白
HMOX1 (Heme Oxygenase (Decycling) 1 (HMOX1))

蛋白类型

Recombinant

宿主

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资源

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大肠杆菌(E. Coli)

纯度

> 95 % as determined by reducing SDS-PAGE.
  • 产品特性

    AA 1-261

    原理

    Recombinant Human Heme Oxygenase 1/HO-1

    序列

    MERPQPDSMP QDLSEALKEA TKEVHTQAEN AEFMRNFQKG QVTRDGFKLV MASLYHIYVA LEEEIERNKE SPVFAPVYFP EELHRKAALE QDLAFWYGPR WQEVIPYTPA MQRYVKRLHE VGRTEPELLV AHAYTRYLGD LSGGQVLKKI AQKALDLPSS GEGLAFFTFP NIASATKFKQ LYRSRMNSLE MTPAVRQRVI EEAKTAFLLN IQLFEELQEL LTHDTKDQSP SRAPGLRQRA SNKVQDSAPV ETPRGKPPLN T

    产品特性

    Recombinant Human Heme Oxygenase 1/HO-1 is produced with our E. coli expression system. The target protein is expressed with sequence (Met1-Thr261) of Human HO-1.

    过滤

    0.2 μm filtered

    内毒素水平

    Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test
  • 想要此Protein的其他选项吗?

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    Product
    表达系统
    Conjugate
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  • 限制

    仅限研究用
  • 状态

    Liquid

    溶解方式

    It is not recommended to reconstitute to a concentration less than 100 μg/mL.
    Dissolve the lyophilized protein in ddH2O.
    Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

    缓冲液

    Supplied as a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, 1 mM EDTA, pH 7.4.

    注意事项

    Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

    储存条件

    -80 °C

    储存方法

    Store at < -20°C, stable for 6 months after receipt.
    Please minimize freeze-thaw cycles.

    有效期

    6 months
  • 抗原

    HMOX1 (Heme Oxygenase (Decycling) 1 (HMOX1))

    别名

    hmox1

    背景

    Heme Oxygenase 1 (HO-1) is an enzyme in endoplasmic reticulum that belongs to the heme oxygenase family. HO-1 cleaves the heme ring at the alpha methene bridge to form Biliverdin. Biliverdin is subsequently converted to Bilirubin by Biliverdin reductase. In physiological state, the highest activity of HO-1 is found in the spleen, where senescent erythrocytes are sequestrated and destroyed. HO-1 activity is highly inducible by its substrate heme and by various non-heme substances such as heavy metals, bromobenzene, endotoxin, oxidizing agents and UVA. HO-1 is involved in the regulation of cardiovascular function and response to a variety of stressors. Defects in HO-1 are the cause of Heme Oxygenase 1 deficiency, resulting in marked erythrocyte fragmentation and intravascular hemolysis, coagulation abnormalities, endothelial damage, and iron deposition in renal and hepatic tissues.
    Alternative Names: Heme Oxygenase 1, HO-1, HMOX1, HO, HO1

    分子量

    29.86 kDa

    UniProt

    P09601

    途径

    Transition Metal Ion Homeostasis, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, SARS-CoV-2 Protein Interactome
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