(PRP40 Pre-mRNA Processing Factor 40 Homolog A (PRPF40A))
Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing.
Jiang, Che, Yuan, Xie, Yan, Hu: "Interaction with polyglutamine-expanded huntingtin alters cellular distribution and RNA processing of huntingtin yeast two-hybrid protein A (HYPA)." in: The Journal of biological chemistry, Vol. 286, Issue 28, pp. 25236-45, (2011) (PubMed).
Allen, Friedler, Schon, Bycroft: "The structure of an FF domain from human HYPA/FBP11." in: Journal of molecular biology, Vol. 323, Issue 3, pp. 411-6, (2002) (PubMed).