The removal of introns from nuclear pre-mRNAs occurs on complexes called spliceosomes, which are made up of 4 small nuclear ribonucleoprotein (snRNP) particles and an undefined number of transiently associated splicing factors. This gene product is one of several proteins that associate with U4 and U6 snRNPs. Mutations in this gene are associated with retinitis pigmentosa-18. [provided by RefSeq, Jul 2008].
Tanackovic, Ransijn, Thibault, Abou Elela, Klinck, Berson, Chabot, Rivolta: "PRPF mutations are associated with generalized defects in spliceosome formation and pre-mRNA splicing in patients with retinitis pigmentosa." in: Human molecular genetics, Vol. 20, Issue 11, pp. 2116-30, (2011) (PubMed).