This gene encodes a liver vitamin K-dependent glycoprotein that is synthesized in the liver and secreted into the plasma. The encoded protein plays a role in regulating blood coagulation by complexing with protein Z-dependent protease inhibitor to directly inhibit activated factor X at the phospholipid surface. Deficiencies in this protein are associated with an increased risk of ischemic arterial diseases and fetal loss. Mutations in this gene are the cause of protein Z deficiency. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012].
Blyth, Favaloro, Harris, Kairaitis: "Protein Z is reduced in chronic kidney disease and not elevated in patients on haemodialysis." in: Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, Vol. 19, Issue 1, pp. 23-5, (2008) (PubMed).
Paidas, Ku, Lee, Manish, Thurston, Lockwood, Arkel: "Protein Z, protein S levels are lower in patients with thrombophilia and subsequent pregnancy complications." in: Journal of thrombosis and haemostasis : JTH, Vol. 3, Issue 3, pp. 497-501, (2005) (PubMed).
Aliases for PROZ 抗体
protein Z, vitamin K dependent plasma glycoprotein (PROZ) 抗体 protein Z, vitamin K-dependent plasma glycoprotein (Proz) 抗体 protein Z, vitamin K-dependent plasma glycoprotein b (prozb) 抗体 hemoglobin Z, beta-like embryonic chain (Hbb-bh1) 抗体 1300015B06Rik 抗体 betaH1 抗体 PZ 抗体