This gene encodes a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. It is found in plasma in both a free, functionally active form and also in an inactive form complexed with C4b-binding protein. Mutations in this gene result in autosomal dominant hereditary thrombophilia. An inactive pseudogene of this locus is located at an adjacent region on chromosome 3. [provided by RefSeq, Feb 2009].
Kariolis, Miao, Jones, Kapur, Mathews, Giaccia, Cochran: "An engineered Axl 'decoy receptor' effectively silences the Gas6-Axl signaling axis." in: Nature chemical biology, Vol. 10, Issue 11, pp. 977-83, (2014) (PubMed).
Aliases for Protein S 蛋白
protein S (PROS1) 蛋白 protein S (Pros1) 蛋白 protein S (pros1) 蛋白 protein S (alpha) (Pros1) 蛋白 AW214361 蛋白 PROS 蛋白 PS21 蛋白 PS22 蛋白 PS23 蛋白 PS24 蛋白 PS25 蛋白 PSA 蛋白 THPH5 蛋白 THPH6 蛋白 zgc:154001 蛋白