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Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D 蛋白

(Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D))
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. [provided by RefSeq, Jul 2008].

7 results :

custom-made PPM1D 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
产品编号 ABIN7561816
 
custom-made PPM1D 宿主: 人 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
产品编号 ABIN7550974
 
PPM1D 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
产品编号 ABIN1315909
 
PPM1D 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant > 90 % pure SDS
产品编号 ABIN5623952
 
custom-made PPM1D 宿主: 小鼠 宿主: Cell-free protein synthesis (CFPS) Recombinant approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC). SDS, ELISA, WB
产品编号 ABIN3130585
 
custom-made PPM1D 宿主: 人 宿主: Cell-free protein synthesis (CFPS) Recombinant approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC). SDS, ELISA, WB
产品编号 ABIN3086448
 
PPM1D 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
产品编号 ABIN2729806
 
  • 类型 Protein
    • Protein
  • 应用范围
    • ELISA
    • SDS-PAGE (SDS)
    • Western Blotting (WB)
    • Affinity Purification (AP)
    • Antibody Array (AA)
    • Antibody Production (AbP)
    • Standard (STD)
  • 适用
    • Human
    • Mouse
  • 图像
  • Carrier free only
  • 抗体来源
    • HEK-293 Cells
    • Cell-free protein synthesis (CFPS)
    • Escherichia coli (E. coli)
    • Wheat germ
  • 抗原表位
    • AA 1-605
    • AA 1-598
    • AA 98-375
  • 标记
    • His tag
    • Strep Tag
    • GST tag
    • Myc-DYKDDDDK Tag
  • 蛋白类型
    • Recombinant
  • Format
    • Liquid
  • Grade
    • custom-made
  • Supplier
    • antibodies-online
    • OriGene

Aliases for Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D 蛋白

protein phosphatase, Mg2+/Mn2+ dependent 1D (PPM1D) 蛋白
protein phosphatase 1D magnesium-dependent, delta isoform (Ppm1d) 蛋白
protein phosphatase, Mg2+/Mn2+ dependent, 1D (Ppm1d) 蛋白
protein phosphatase, Mg2+/Mn2+ dependent, 1Db (ppm1db) 蛋白
protein phosphatase, Mg2+/Mn2+ dependent 1D L homeolog (ppm1d.L) 蛋白
protein phosphatase, Mg2+/Mn2+ dependent, 1Da (ppm1da) 蛋白
AV338790 蛋白
PP2C-DELTA 蛋白
ppm1d 蛋白
WIP1 蛋白
Wip1 蛋白
wu:fj44c08 蛋白
zgc:55836 蛋白
zgc:77316 蛋白
zgc:103518 蛋白
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