Protein Phosphatase 4, Regulatory Subunit 2 蛋白
(Protein Phosphatase 4, Regulatory Subunit 2 (PPP4R2))
Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair (By similarity). Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage- dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair (By similarity).
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Aliases for Protein Phosphatase 4, Regulatory Subunit 2 蛋白
protein phosphatase 4 regulatory subunit 2 (PPP4R2) 蛋白protein phosphatase 4, regulatory subunit 2 (Ppp4r2) 蛋白
protein phosphatase 4, regulatory subunit 2a (ppp4r2a) 蛋白
protein phosphatase 4 regulatory subunit 2 S homeolog (ppp4r2.S) 蛋白
protein phosphatase 4 regulatory subunit 2 (ppp4r2) 蛋白
protein phosphatase 4 regulatory subunit 2 L homeolog (ppp4r2.L) 蛋白
protein phosphatase 4, regulatory subunit 2b (ppp4r2b) 蛋白
BE691708 蛋白
C230060M08Rik 蛋白
fe11b04 蛋白
PP4R2 蛋白
ppp4r2 蛋白
ppp4r2-B 蛋白
wu:fa17h08 蛋白
wu:fc23g05 蛋白
wu:fe11b04 蛋白
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