Protamines are the major DNA-binding proteins in the nucleus of sperm, and package the DNA in a volume less than 5% of a somatic cell nucleus (summarized by Cho et al., 2001 [PubMed 11326282]). See PRM1 (MIM 182880).[supplied by OMIM, Jul 2010].
Djureinovic, Fagerberg, Hallström, Danielsson, Lindskog, Uhlén, Pontén: "The human testis-specific proteome defined by transcriptomics and antibody-based profiling." in: Molecular human reproduction, Vol. 20, Issue 6, pp. 476-88, (2014) (PubMed).