The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. [provided by RefSeq, Jul 2008].
Popular PRKAB2 蛋白
Aliases for PRKAB2 蛋白
protein kinase, AMP-activated, beta 2 non-catalytic subunit L homeolog (prkab2.L) 蛋白 protein kinase AMP-activated non-catalytic subunit beta 2 (PRKAB2) 蛋白 protein kinase, AMP-activated, beta 2 non-catalytic subunit (PRKAB2) 蛋白 protein kinase, AMP-activated, beta 2 non-catalytic subunit (prkab2) 蛋白 protein kinase, AMP-activated, beta 2 non-catalytic subunit (Prkab2) 蛋白 protein kinase AMP-activated non-catalytic subunit beta 2 (Prkab2) 蛋白 5730553K21Rik 蛋白 AW049591 蛋白 BB124140 蛋白 DKFZp469M1118 蛋白 MGC64365 蛋白 prkab2 蛋白 PRKAB2 蛋白