(Phosphatidic Acid Phosphatase Type 2 Domain Containing 2 (PPAPDC2))
Phosphatase that dephosphorylates presqualene diphosphate (PSDP) into presqualene monophosphate (PSMP), suggesting that it may be indirectly involved in innate immunity. PSDP is a bioactive lipid that rapidly remodels to presqualene monophosphate PSMP upon cell activation. Displays diphosphate phosphatase activity with a substrate preference for PSDP > FDP > phosphatidic acid (By similarity).
Pant, Kocarek: "Role of Phosphatidic Acid Phosphatase Domain Containing 2 in Squalestatin 1-Mediated Activation of the Constitutive Androstane Receptor in Primary Cultured Rat Hepatocytes." in: Drug metabolism and disposition: the biological fate of chemicals, Vol. 44, Issue 3, pp. 352-5, (2016) (PubMed).