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抗Human HTRA2 抗体:
抗Mouse (Murine) HTRA2 抗体:
抗Rat (Rattus) HTRA2 抗体:
Human Polyclonal HTRA2 Primary Antibody for IF, WB - ABIN223216
Griparic, Kanazawa, van der Bliek: Regulation of the mitochondrial dynamin-like protein Opa1 by proteolytic cleavage. in The Journal of cell biology 2007
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Human Monoclonal HTRA2 Primary Antibody for IHC (p), IHC - ABIN252514
Laforge, Bidère, Carmona, Devocelle, Charpentier, Senik: Apoptotic death concurrent with CD3 stimulation in primary human CD8+ T lymphocytes: a role for endogenous granzyme B. in Journal of immunology (Baltimore, Md. : 1950) 2006
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Human Monoclonal HTRA2 Primary Antibody for IHC (p), WB - ABIN532000
Lee, Lee, Kim, Kim, Park, Kim, Lee, Yoo: Immunohistochemical analysis of Omi/HtrA2 expression in stomach cancer. in APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2003
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Mitochondrial serine protease HtrA2 (显示 F2 抗体)/Omi is an important mediator of germ cell death.
Data show the presence of apoptosis at the cellular level in both ade2 (显示 PAICS 抗体) and Prat (显示 PPAT 抗体) mutants, and the upregulated gene HtrA2, which encodes an apoptosis effector and is thus a candidate for initiating apoptosis in response to purine depletion.
Drosophila Omi (dOmi), a fly homologue of the serine protease Omi/HtrA2, alleviates th/DIAP1 (显示 DIAPH1 抗体) inhibition of all caspases by proteolytically degrading th/DIAP1 (显示 DIAPH1 抗体) and induces apoptosis both in cultured cells and in the developing fly eye.
The binding of DIAP1 (显示 DIAPH1 抗体) to dOmi resulted in DIAP1 (显示 DIAPH1 抗体)-mediated polyubiquitination of dOmi, suggesting that DIAP1 (显示 DIAPH1 抗体) could target dOmi for proteasomal degradation.
found that Rhomboid-7, a mitochondrial protease not previously implicated in PD, acts as an upstream component of this pathway, and showed that it is required to cleave the precursor forms of both Pink1 (显示 PINK1 抗体) and Omi
HtrA2 was shown to be phosphorylated in a PINK1 (显示 PINK1 抗体)-dependent manner, suggesting it might act in the PINK1 (显示 PINK1 抗体) pathway.
The association between the change in HtrA2 and proteins associated with LATS1 (显示 LATS1 抗体) in ovarian serous cancer cell lines after repeated treatment with cisplatin was evaluated in vitro. In immunohistochemical analysis, repeated cisplatin treatment induced downregulation of HtrA2 protein expression, before and after cisplatin-based chemotherapy in SAC (显示 ADCY10 抗体).
STEMI patients with elevated circulating HtrA2 levels were identified as having ischemia-reperfusion injury.
The important functions for HTRA2 in programmed cell death.
A pathogenic role of serine protease HtrA2 (显示 F2 抗体) in Parkinson's and Alzheimer's diseases has been described. (Review)
The first report of recessive deleterious mutations in HTRA2 in human. Absence of HTRA2/Omi is associated with severe neurodegenerative disorder of infancy, abnormal mitochondria, 3-methylglutaconic aciduria and increased sensitivity to apoptosis.
HTRA2 and ANO3 (显示 ANO3 抗体) mutations are not common causes of essential tremor
HtrA2 under stress conditions induces vimentin (显示 VIM 抗体) cleavage in wild-type and SH-SY5Y cells transfected with ABP (显示 ABP1 抗体) with the Alzheimer disease-associated Swedish mutation. Interplay between Omi/HtrA2 and vimentin (显示 VIM 抗体) affects mitochondrial distribution in neurons.
The a5 helix of PDZ (显示 INADL 抗体) was involved in both, the intra- and intersubunit changes of interactions and thus seems to play an important role in HtrA2 activation.
study examined the association of HTRA2 p.G399S mutation with essential tremor(ET) and Parkinson disease (PD) in Asians and found that HTRA2 p.G399S is rare and does not appear to play a major role in subjects with coexistent ET and PD nor in those with pure ET or PD phenotype
The NG2 (显示 MCSP 抗体) proteoglycan (显示 Vcan 抗体) protects oligodendrocyte precursor cells against oxidative stress via interaction with OMI/HtrA2.
The therapeutic function of HtrA2 in inflammatory diseases is linked with Th17 development and the STAT3 (显示 STAT3 抗体) pathway in splenocytes.
Study show that overexpression of mitochondrial Omi/HtrA2 induces cardiac apoptosis and dysfunction.
Omi/HtrA2-HAX-1 (显示 HAX1 抗体) chain played a significant role in mitochondrial homeostasis.
Mice overexpressing wild-type or G399S mutant HtrA2 have mitochondrial defects resulting in neurodegeneration.
Protease Omi facilitates neurite outgrowth by cleaving the transcription factor E2F1 (显示 E2F1 抗体) in differentiated neuroblastoma (显示 ARHGEF16 抗体) cells; E2F1 (显示 E2F1 抗体) is a substrate of Omi.
Protease Omi impairs mitochondrial function by cleaving Hax-1 (显示 HAX1 抗体), which induces apoptosis in oxygen-glucose deprivation and reoxygenation -treated N2a cells and causes reperfusion injury in middle cerebral artery occlusion mice.
The NG2 (显示 Vcan 抗体) proteoglycan (显示 Vcan 抗体) protects oligodendrocyte precursor cells against oxidative stress via interaction with OMI/HtrA2.
Loss of Omi protease activity results in an abnormal increase of GSK3b, leading to the degradation of PGC (显示 PGC 抗体)-1a, which causes an impairment of mitochondrial biogenesis and induces neurodegeneration.
Neural-specific deletion of Htra2 causes cerebellar neurodegeneration and defective processing of mitochondrial OPA1 (显示 MED12 抗体).
Inactivation of Omi/HtrA2 protease leads to the deregulation of mitochondrial Mulan E3 ubiquitin ligase (显示 MUL1 抗体) and increased mitophagy.
This gene encodes a serine protease. The protein has been localized in the endoplasmic reticulum and interacts with an alternatively spliced form of mitogen-activated protein kinase 14. The protein has also been localized to the mitochondria with release to the cytosol following apoptotic stimulus. The protein is thought to induce apoptosis by binding the apoptosis inhibitory protein baculoviral IAP repeat-containing 4. Nuclear localization of this protein has also been observed. Alternate splicing of this gene results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined.
, HtrA serine peptidase 2
, protease, serine, 25
, serine protease HTRA2, mitochondrial-like
, HtrA-like serine protease
, Omi stress-regulated endoprotease
, high temperature requirement protein A2
, serine protease 25
, serine protease HTRA2, mitochondrial
, serine proteinase OMI
, motor neuron degeneration 2
, omi stress-regulated endoprotease
, serine protease OMI
, protease serine 25