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Human Polyclonal Adrm1 Primary Antibody for WB - ABIN1881049
Mazumdar, Gorgun, Sha, Tyryshkin, Zeng, Hartmann-Petersen, Jørgensen, Hendil, Eissa: Regulation of NF-kappaB activity and inducible nitric oxide synthase by regulatory particle non-ATPase subunit 13 (Rpn13). in Proceedings of the National Academy of Sciences of the United States of America 2010
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Human Monoclonal Adrm1 Primary Antibody for IF, IP - ABIN564790
Pece, Tosoni, Confalonieri, Mazzarol, Vecchi, Ronzoni, Bernard, Viale, Pelicci, Di Fiore: Biological and molecular heterogeneity of breast cancers correlates with their cancer stem cell content. in Cell 2010
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We show that ADRM1 mRNA overexpression is an early event in high grade serous carcinoma of the ovary. This is associated with TP53 mutation and increased burden of misfolded proteins in carcinomas that likely renders the cancer cells particularly sensitive to RPN13 inhibitors.
evidence that the interaction can mediate the association of Rpn13 and SGTA (显示 SGTA 抗体) in a cellular context.
The structures of proteasome substrate receptor complexes with the shuttle factors that deliver ubiquitinated proteins to proteasomes have been solved, namely human Rpn13 complexed with PLIC2 (显示 UBQLN2 抗体) and Saccharomyces cerevisiae Rpn1 (显示 PSMD2 抗体) with Rad23.
RPN13 binds ubiquitin with an affinity similar to that of other proteasome-associated ubiquitin receptors and that RPN2, ubiquitin, and the deubiquitylase UCH37 bind to RPN13 with independent energetics.
regulation of NY-ESO-1 processing by the ubiquitin receptors Rpn10 and Rpn13 as a well as by the standard and immunoproteasome is governed by non-canonical ubiquitination on non-lysine sites.
this work implicates hRpn13 and Uch37 (显示 UCHL5 抗体) in cell cycle progression, providing a rationale for their function in cellular proliferation and for the apoptotic effect of the hRpn13-targeting molecule RA190.
the binding of SGTA to Rpn13 enables specific polypeptides to escape proteasomal degradation and/or selectively modulates substrate degradation.
Data suggest that ADRM1 is involved in proliferation of acute leukemia cells; expression of ADRM1 is up-regulated in leukemia; knockdown of ADRM1 inhibits cell proliferation at G0/G1 phase of cell cycle but does not affect apoptosis/cell migration.
findings implicate Rpn13 in linking parkin (显示 PARK2 抗体) to the 26 S proteasome and regulating the clearance of mitochondrial proteins during mitophagy
Data show that DEUBAD domain in RPN13 (ADRM1) activates ubiquitin thioesterase L5 (UCH-L5 (显示 UCHL5 抗体)), and the related DEUBAD domain in INO80G (NFRKB (显示 NFRKB 抗体)) inhibits UCH-L5 (显示 UCHL5 抗体).
Data show that either Rpn13 knock down or RA190 treatment reduced the capacity of myeloid-derived-suppressor cells (MDSCs) to suppress T cell proliferation in vitro.
this study showed that Rpn13 plays a redundant role with Rpn10 (显示 Psmd4 抗体) in recognition and degradation of ubiquitinated proteins in mouse livers.
this is the first report characterizing the physiological roles of Uch37 and Rpn13 in murine development and implicating a non-ATPase proteasomal protein, Rpn13, in the process of gametogenesis
show that Rpn13 is involved in inducible nitric oxide synthase (显示 NOS2 抗体) degradation and is required for iNOS (显示 NOS2 抗体) interaction with the deubiquitination protein UCH37 (显示 UCHL5 抗体).
ARM-1 is a cytosolic protein associated with the plasma membrane. However, no cell surface expression of the protein was observed. These results suggest an indirect role of ARM-1 in adhesion rather than a direct role as an adhesion molecule (显示 NCAM1 抗体) itself.
identification of a new ubiquitin receptor, Rpn13/ARM1, a known component of the proteasome
crystallography and NMR data to describe the ubiquitin-binding mechanism of Rpn13
The protein encoded by this gene is an integral plasma membrane protein which promotes cell adhesion. The encoded protein is thought to undergo O-linked glycosylation. Expression of this gene has been shown to be induced by gamma interferon in some cancer cells. Two transcript variants encoding the same protein have been found for this gene.
proteasomal ubiquitin receptor ADRM1
, adhesion regulating molecule 1
, ADRM1 protein
, 110 kDa cell membrane glycoprotein
, M(r) 110,000 surface antigen
, proteasome regulatory particle non-ATPase 13
, rpn13 homolog
, adhesion-regulating molecule 1
, glycoprotein 110
, cell membrane glycoprotein, 110000M(r) (surface antigen)
, adhesion regulating molecule 1a
, adhesion regulating molecule 1b