This gene encodes a tissue-restricted nuclear transcriptional activator that is preferentially expressed in lymphoid tissue. Isolation of this protein initially defined a highly conserved LAF4/MLLT2 gene family of nuclear transcription factors that may function in lymphoid development and oncogenesis. In some ALL patients, this gene has been found fused to the gene for MLL. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Jul 2008].
To, Faseruk, Gokgoz, Pinnaduwage, Done, Andrulis: "LAF-4 is aberrantly expressed in human breast cancer." in: International journal of cancer. Journal international du cancer, Vol. 115, Issue 4, pp. 568-74, (2005) (PubMed).
Hiwatari, Taki, Taketani, Taniwaki, Sugita, Okuya, Eguchi, Ida, Hayashi: "Fusion of an AF4-related gene, LAF4, to MLL in childhood acute lymphoblastic leukemia with t(2;11)(q11;q23)." in: Oncogene, Vol. 22, Issue 18, pp. 2851-5, (2003) (PubMed).
von Bergh, Beverloo, Rombout, van Wering, van Weel, Beverstock, Kluin, Slater, Schuuring: "LAF4, an AF4-related gene, is fused to MLL in infant acute lymphoblastic leukemia." in: Genes, chromosomes & cancer, Vol. 35, Issue 1, pp. 92-6, (2002) (PubMed).
Aliases for AFF3 抗体
AF4/FMR2 family member 3 (AFF3) 抗体 AF4/FMR2 family, member 3 (aff3) 抗体 AF4/FMR2 family, member 3 (Aff3) 抗体 3222402O04Rik 抗体 A730046J16 抗体 id:ibd5053 抗体 LAF-4 抗体 LAF4 抗体 Laf4 抗体 MLLT2-like 抗体