(Polymerase (RNA) III (DNA Directed) Polypeptide B (POLR3B))
This gene encodes the second largest subunit of RNA polymerase III, the polymerase responsible for synthesizing transfer and small ribosomal RNAs in eukaryotes. The largest subunit and the encoded protein form the catalytic center of RNA polymerase III. Mutations in this gene are a cause of hypomyelinating leukodystrophy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011].
Shen, Lei, Liu, Zheng, Song, Marc, Wang, Sun, Liang: "Identification and characterization of INMAP, a novel interphase nucleus and mitotic apparatus protein that is involved in spindle formation and cell cycle progression." in: Experimental cell research, Vol. 315, Issue 7, pp. 1100-16, (2009) (PubMed).
Yee, Gong, Huang, Lorent, Dolan, Maraia, Pack: "Mutation of RNA Pol III subunit rpc2/polr3b Leads to Deficiency of Subunit Rpc11 and disrupts zebrafish digestive development." in: PLoS biology, Vol. 5, Issue 11, pp. e312, (2007) (PubMed).
Aliases for POLR3B 抗体
RNA polymerase III subunit B (Polr3b) 抗体 RNA polymerase III subunit B (POLR3B) 抗体 polymerase (RNA) III (DNA directed) polypeptide B (Polr3b) 抗体 2700078H01Rik 抗体 A330032P03Rik 抗体 C128 抗体 C85372 抗体 HLD8 抗体 RGD1565311 抗体 RPC2 抗体