(Polymerase (RNA) II (DNA Directed) Polypeptide E, 25kDa (POLR2E))
This gene encodes the fifth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases and is present in two-fold molar excess over the other polymerase subunits. An interaction between this subunit and a hepatitis virus transactivating protein has been demonstrated, suggesting that interaction between transcriptional activators and the polymerase can occur through this subunit. A pseudogene is located on chromosome 11. [provided by RefSeq, Jul 2008].
Frischknecht, Britschgi, Galliker, Christinat, Vichalkovski, Gstaiger, Kovacs, Krek: "BRAF inhibition sensitizes melanoma cells to α-amanitin via decreased RNA polymerase II assembly." in: Scientific reports, Vol. 9, Issue 1, pp. 7779, (2019) (PubMed).
Aliases for POLR2E 抗体
polymerase (RNA) II (DNA directed) polypeptide E, 25kDa S homeolog (polr2e.S) 抗体 RNA polymerase II subunit E (POLR2E) 抗体 polymerase (RNA) II (DNA directed) polypeptide E, b (polr2eb) 抗体 polymerase (RNA) II (DNA directed) polypeptide E, 25kDa (polr2e) 抗体 polymerase (RNA) II (DNA directed) polypeptide E (Polr2e) 抗体 RNA polymerase II subunit E (Polr2e) 抗体 DNA-directed RNA polymerases I, II, and III subunit RPABC1 (rpb-5) 抗体 25kDa 抗体 2410021N14Rik 抗体 AW208866 抗体 hRPB25 抗体 hsRPB5 抗体 MGC68604 抗体 polr2e 抗体 RPABC1 抗体 RPB5 抗体 wu:fk97g10 抗体 XAP4 抗体 zgc:101098 抗体