(Polymerase (RNA) II (DNA Directed) Polypeptide B, 140kDa (POLR2B))
This gene encodes the second largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit, in combination with at least two other polymerase subunits, forms a structure within the polymerase that maintains contact in the active site of the enzyme between the DNA template and the newly synthesized RNA. [provided by RefSeq, Jul 2008].
Jönsson, Ludvik Brattås, Gustafsson, Petri, Yudovich, Pircs, Verschuere, Madsen, Hansson, Larsson, Månsson, Meissner, Jakobsson: "Activation of neuronal genes via LINE-1 elements upon global DNA demethylation in human neural progenitors." in: Nature communications, Vol. 10, Issue 1, pp. 3182, (2019) (PubMed).
Lee, Skalnik: "Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes." in: Molecular and cellular biology, Vol. 28, Issue 2, pp. 609-18, (2008) (PubMed).
Minamishima, Moslehi, Bardeesy, Cullen, Bronson, Kaelin: "Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure." in: Blood, Vol. 111, Issue 6, pp. 3236-44, (2008) (PubMed).
Aliases for POLR2B 抗体
RNA polymerase II subunit B (POLR2B) 抗体 polymerase (RNA) II (DNA directed) polypeptide B, 140kDa (polr2b) 抗体 RNA polymerase II subunit B (polr2b) 抗体 DNA-directed RNA polymerase II subunit RPB2 (LOC100640211) 抗体 polymerase (RNA) II (DNA directed) polypeptide B (Polr2b) 抗体 RNA polymerase II subunit B (Polr2b) 抗体 polymerase (RNA) II (DNA directed) polypeptide B, 140kDa L homeolog (polr2b.L) 抗体 DNA-directed RNA polymerase II subunit RPB2 (rpb-2) 抗体 hRPB140 抗体 hsRPB2 抗体 Pol2rb 抗体 POL2RB 抗体 Rpb2 抗体 RPB2 抗体 Rpb140 抗体