This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA\; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum. [provided by RefSeq, Jul 2008].
custom-made
POLH
宿主: 小鼠
宿主: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
WB, ELISA, SDS
custom-made
POLH
宿主: 人
宿主: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
WB, ELISA, SDS
polymerase (DNA directed), eta S homeolog (polh.S) 蛋白 DNA polymerase eta (POLH) 蛋白 polymerase (DNA directed), eta (polh) 蛋白 DNA polymerase eta (Tb10.70.6190) 蛋白 putative DNA polymerase eta (LINJ_21_0690) 蛋白 polymerase (DNA directed), eta (Polh) 蛋白 DNA polymerase eta (LOC100443019) 蛋白 DNA polymerase eta (polh) 蛋白 DNA polymerase eta (Polh) 蛋白 polymerase (DNA directed), eta (RAD 30 related) (Polh) 蛋白 fc50a12 蛋白 POLH 蛋白 RAD30 蛋白 RAD30A 蛋白 wu:fc50a12 蛋白 XP-V 蛋白 XPV 蛋白 zgc:136881 蛋白 zgc:152642 蛋白