POLH 抗体
(Polymerase (DNA Directed), eta (POLH))
This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA\; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum. [provided by RefSeq, Jul 2008].
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Latest Publications for our POLH 抗体
: "c-Jun N-terminal kinase-mediated Rad18 phosphorylation facilitates Polη recruitment to stalled replication forks." in: Molecular biology of the cell, Vol. 23, Issue 10, pp. 1943-54, (2012) (PubMed).: "Phosphorylated Rad18 directs DNA polymerase η to sites of stalled replication." in: The Journal of cell biology, Vol. 191, Issue 5, pp. 953-66, (2010) (PubMed).
: "Contributions of ubiquitin- and PCNA-binding domains to the activity of Polymerase eta in Saccharomyces cerevisiae." in: Nucleic acids research, Vol. 35, Issue 3, pp. 881-9, (2007) (PubMed).
: "Polymerase eta is a short-lived, proteasomally degraded protein that is temporarily stabilized following UV irradiation in Saccharomyces cerevisiae." in: Journal of molecular biology, Vol. 366, Issue 4, pp. 1074-86, (2007) (PubMed).
: "The DNA sequence and analysis of human chromosome 6. ..." in: Nature, Vol. 425, Issue 6960, pp. 805-11, (2003) (PubMed).
: "Mutations in human DNA polymerase eta motif II alter bypass of DNA lesions." in: The EMBO journal, Vol. 20, Issue 24, pp. 7303-12, (2001) (PubMed).
: "Genomic structure, chromosomal localization and identification of mutations in the xeroderma pigmentosum variant (XPV) gene." in: Oncogene, Vol. 19, Issue 41, pp. 4721-8, (2000) (PubMed).
: "The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta." in: Nature, Vol. 399, Issue 6737, pp. 700-4, (1999) (PubMed).
: "hRAD30 mutations in the variant form of xeroderma pigmentosum." in: Science (New York, N.Y.), Vol. 285, Issue 5425, pp. 263-5, (1999) (PubMed).
Aliases for POLH 抗体
polymerase (DNA directed), eta S homeolog (polh.S) 抗体DNA polymerase eta (POLH) 抗体
polymerase (DNA directed), eta (polh) 抗体
DNA polymerase eta (Tb10.70.6190) 抗体
putative DNA polymerase eta (LINJ_21_0690) 抗体
polymerase (DNA directed), eta (Polh) 抗体
DNA polymerase eta (LOC100443019) 抗体
DNA polymerase eta (polh) 抗体
DNA polymerase eta (Polh) 抗体
polymerase (DNA directed), eta (RAD 30 related) (Polh) 抗体
fc50a12 抗体
POLH 抗体
RAD30 抗体
RAD30A 抗体
wu:fc50a12 抗体
XP-V 抗体
XPV 抗体
zgc:136881 抗体
zgc:152642 抗体
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