This gene encodes the 66-kDa subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein plays a role in regulating the activity of DNA polymerase delta through interactions with other subunits and the processivity cofactor proliferating cell nuclear antigen (PCNA). Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Mar 2012].
Bursomanno, Beli, Khan, Minocherhomji, Wagner, Bekker-Jensen, Mailand, Choudhary, Hickson, Liu: "Proteome-wide analysis of SUMO2 targets in response to pathological DNA replication stress in human cells." in: DNA repair, Vol. 25, pp. 84-96, (2014) (PubMed).
Johnson, ODonnell: "Cellular DNA replicases: components and dynamics at the replication fork." in: Annual review of biochemistry, Vol. 74, pp. 283-315, (2005) (PubMed).
Shikata, Ohta, Yamada, Obuse, Yoshikawa, Tsurimoto: "The human homologue of fission Yeast cdc27, p66, is a component of active human DNA polymerase delta." in: Journal of biochemistry, Vol. 129, Issue 5, pp. 699-708, (2001) (PubMed).
Hindges, Hübscher: "DNA polymerase delta, an essential enzyme for DNA transactions." in: Biological chemistry, Vol. 378, Issue 5, pp. 345-62, (1997) (PubMed).