PML 抗体
(Promyelocytic Leukemia (PML))
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions\; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
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Latest Publications for our PML 抗体
: "Proteomic characterization of arsenic and cadmium exposure in bladder cells." in: Rapid communications in mass spectrometry : RCM, (2019) (PubMed).: "Autophagy and Ubiquitin-Mediated Proteolytic Degradation of PML/Rarα Fusion Protein in Matrine-Induced Differentiation Sensitivity Recovery of ATRA-Resistant APL (NB4-LR1) Cells: in Vitro and in Vivo ..." in: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Vol. 48, Issue 6, pp. 2286-2301, (2018) (PubMed).
: "Evidence for Kaposi Sarcoma Originating from Mesenchymal Stem Cell through KSHV-induced Mesenchymal-to-Endothelial Transition." in: Cancer research, Vol. 78, Issue 1, pp. 230-245, (2018) (PubMed).
: "Visualization of PML nuclear import complexes reveals FG-repeat nucleoporins at cargo retrieval sites." in: Nucleus (Austin, Tex.), Vol. 8, Issue 4, pp. 404-420, (2018) (PubMed).
: "The Smc5/6 Complex Restricts HBV when Localized to ND10 without Inducing an Innate Immune Response and Is Counteracted by the HBV X Protein Shortly after Infection." in: PLoS ONE, Vol. 12, Issue 1, pp. e0169648, (2017) (PubMed).
: "Sp100A is a tumor suppressor that activates p53-dependent transcription and counteracts E1A/E1B-55K-mediated transformation." in: Oncogene, Vol. 35, Issue 24, pp. 3178-89, (2016) (PubMed).
: "An Adenovirus DNA Replication Factor, but Not Incoming Genome Complexes, Targets PML Nuclear Bodies." in: Journal of virology, Vol. 90, Issue 3, pp. 1657-67, (2016) (PubMed).
: "The Arginine/Lysine-Rich Element within the DNA-Binding Domain Is Essential for Nuclear Localization and Function of the Intracellular Pathogen Resistance 1." in: PLoS ONE, Vol. 11, Issue 9, pp. e0162832, (2016) (PubMed).
: "PML isoforms IV and V contribute to adenovirus-mediated oncogenic transformation by functionally inhibiting the tumor-suppressor p53." in: Oncogene, Vol. 35, Issue 1, pp. 69-82, (2016) (PubMed).
: "KLHL39 suppresses colon cancer metastasis by blocking KLHL20-mediated PML and DAPK ubiquitination." in: Oncogene, Vol. 34, Issue 40, pp. 5141-51, (2015) (PubMed).
Aliases for PML 抗体
promyelocytic leukemia (PML) 抗体promyelocytic leukemia (Pml) 抗体
1200009E24Rik 抗体
AI661194 抗体
MYL 抗体
PML 抗体
PP8675 抗体
RGD1562602 抗体
RNF71 抗体
TRIM19 抗体
Trim19 抗体
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