Cardiolipin hydrolase present at the mitochondrial outer membrane required both for mitochondrial fusion and piRNA metabolic process. Acts by catalyzing the hydrolysis of cardiolipin (diphosphatidylglycerol) to form phosphatidate (phosphatidic acid or PA) at the mitochondrial outer membrane surface, promoting mitochondrial fusion. The production of phosphatidate also regulates the piRNA metabolic process by promoting recruitment and/or activation of components of the meiotic nuage, also named P granule, a critical step for primary biogenesis of piRNAs. Required during spermatogenesis to repress transposable elements and prevent their mobilization via its role in the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons (By similarity).
phospholipase D family member 6 (PLD6) 抗体 phospholipase D family, member 6 (Pld6) 抗体 phospholipase D family member 6 S homeolog (pld6.S) 抗体 phospholipase D family, member 6 (pld6) 抗体 4933433K01Rik 抗体 fc55d08 抗体 Gm10 抗体 mitoPLD 抗体 mZuc 抗体 pld6 抗体 wu:fc55d08 抗体 ZUC 抗体 Zuc 抗体