PLD6 抗体 (AA 39-238) (Biotin)
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北京 101111
Quick Overview for PLD6 抗体 (AA 39-238) (Biotin) (ABIN8022202)
抗原
See all PLD6 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 39-238
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原理
- Anti-PLD6 Antibody Biotin Conjugated
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human PLD6 recombinant protein (Position: R39-L238).
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亚型
- IgG
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anti-Phospholipase D Family, Member 6 (PLD6) (AA 125-154) antibody
PLD6 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB28958 unconjugated
anti-Phospholipase D Family, Member 6 (PLD6) (AA 1-252) antibodyPLD6 适用: 人 ELISA, WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Phospholipase D Family, Member 6 (PLD6) (AA 125-154) antibodyPLD6 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.
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有效期
- 12 months
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- PLD6 (Phospholipase D Family, Member 6 (PLD6))
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别名
- PLD6
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背景
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Background: PLD6 (phospholipase D family, member 6) is a protein-coding gene. Among its related super-pathways are choline biosynthesis III and Glycerophospholipid biosynthesis. GO annotations related to this gene include cardiolipin hydrolase activity and protein homodimerization activity. Regulates mitochondrial shape through facilitating mitochondrial fusion. During spermatogenesis, plays a critical role in PIWI-interacting RNA (piRNA) biogenesis (By similarity). piRNAs provide essential protection against the activity of mobile genetic elements. piRNA-mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation. Has been shown to be a backbone-non-specific, single strand-specific nuclease, cleaving either RNA or DNA substrates with similar affinity (By similarity). Produces 5' phosphate and 3' hydroxyl termini, suggesting it could ly participate in the processing of primary piRNA transcripts (By similarity). Has been proposed to act as a cardiolipin hydrolase to generate phosphatidic acid at mitochondrial surface. Although it cannot be excluded that it can act as a phospholipase in some circumstances, it should be noted that cardiolipin hydrolase activity is either undetectable in vitro, or very low (PubMed:21397848). In addition, cardiolipin is almost exclusively found on the inner mitochondrial membrane, while PLD6 localizes to the outer mitochondrial membrane, facing the cytosol.
Gene Full Name: phospholipase D family member 6
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基因ID
- 201164
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UniProt
- Q8N2A8
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途径
- Ribonucleoprotein Complex Subunit Organization
抗原
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